[NVIC] Can DPT/DTaP Alter Immune Function?

Vienna, Virginia http://www.nvic.org

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"Protecting the health and informed consent rights of children since 1982."

BL Fisher Note:

Pertussis toxin is present in both DPT and DtaP vaccines, although it is
less bioactive in DTaP vaccine.  Research four and five decades ago on DPT
vaccine suggested it had a marked ability to induce brain and immune system
dysfunction. The research described below adds to a body of knowledge that
pertussis toxin, one of the most lethal toxins in nature, has profound
biological effects which may impact to a lesser or greater degree on the
neuroimmune function of infants injected with DPT or DTaP.  DPT was the
first vaccine to be associated with autism in the book "DPT: A Shot in the
Dark" (Coulter &Fisher) published in 1985 and many of the DPT vaccine injury
case reports in that book described infants who were allergic to milk prior
to vaccination or became allergic to milk after a vaccine reaction had taken

Pertussis adjuvant prolongs intestinal hypersensitivity.
Kosecka U, Berin MC, Perdue MH.

Intestinal Disease Research Programme, and Department of Pathology and
Molecular Medicine, McMaster University, Hamilton, Ont., Canada.

BACKGROUND: Immediate hypersensitivity reactions are a hallmark of allergic
disease, and result in the clinical features of food allergy, hayfever, and
atopic asthma. The mechanism by which an individual becomes sensitized to an
ingested or airborne allergen is not clear, however exposure to bacteria or
bacterial products that act as adjuvants may be a contributing factor. The
purpose of this study was to examine the role of pertussis toxin (PT) in
inducing intestinal hypersensitivity reactions, particularly the ability of
the adjuvant to prolong the sensitization. METHODS: Rats were sensitized to
ovalbumin (OA) by injection of OA alone or with 50 ng PT. Secretory
responses to OA challenge and nerve stimulation were assessed in jejunal
tissues mounted in Ussing chambers. RESULTS: Jejunal segments from rats
sensitized to OA alone responded to antigen challenge with ion secretion,
but sensitization was transient in that specific IgE titers and responses to
luminal antigen disappeared by 14 days. In contrast, co-administration of 50
ng PT with OA resulted in long-lasting sensitization. Secretory responses to
both luminal and serosal OA challenge were present 8 months after primary
immunization. Enhanced secretory responses to nerve stimulation, increased
mucosal mast cell numbers, as well as elevated IgE titers were also induced
and may have contributed to the overall responsiveness of the intestine to
antigen challenge. CONCLUSIONS: Our findings indicate nanogram quantities of
PT, when administered with a food protein, result in long-term sensitization
to the antigen, and altered intestinal neuroimmune function. These data
suggest that exposure to bacterial pathogens may prolong the normally
transient immune responsiveness to inert food antigens.