Chlorpromazine (Thorazine, Largactil) advertising

Chlorpromazine (Thorazine, Largactil) advertising
Thorazine Psychiatry ads

Thorazine advertisement, circa 1960
Patients with pain often have anxiety -- Patients with anxiety often have pain
ThorazineŽ brand of chlorpromazine
helps reduce reaction to pain, relieves anxiety -- helps relieve anxiety, reduces reaction to pain
Smith Kline & French Laboratories

Thorazine advertisement, 1956.
Psychosomatic Medicine, Vol. 18, No. 5.
THORAZINE
helps relieve the emotional stress that complicates so many somatic disorders...
...for example, as an adjuvant in ARTHRITIS
THORAZINE helps:
to ease anxiety and frustration
to relieve the general suffering
to promote normal sleep habits
It goes without saying that not all arthritic patients are benefited by 'Thorazine' therapy.
'Thorazine' is most useful when the psychic element is important.
Smith Kline & French Laboratories, Philadelphia
T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisements, 1956 & 1959

FOR IMMEDIATE EFFECT!
in acute alcoholism
THORAZINE Ampuls
'Thorazine' should be used discriminately and, before
prescribing, the physician should be fully conversant
with the available literature.
always carry 'Thorazine' Ampuls in your bag
Smith Kline & French Laboratories, Philadelphia
T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.
PROMPT CONTROL OF
ACUTE ALCOHOLISM
THORAZINE Injection
Ampuls and Multiple dose vials
Smith Kline & French Laboratories
T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1956

in severe asthma...
Relief of psychic stress is often as important as control of offending allergens in the successful treatment of many patients with severe asthma.
THORAZINE can be highly effective...
'Thorazine' has a definite place in the treatment of severe asthma. The unique ataraxic, tranquilizing effect of 'Thorazine' controls the emotional
processes which may either cause or aggravate and prolong the severe asthmatic attack.
Furthermore, 'Thorazine' -- unlike calming agents previously used -- causes little or no respiratory depression.
It goes without saying that not all cases of asthma are suitable for 'Thorazine' therapy.
'Thorazine' is most useful when the psychic element is important.
'Thorazine' should be used discriminately and, before prescribing, the physician should be fully conversant with the available literature.
'Thorazine' is available in ampuls, tablets and syrup (as the hydrochloride), and in suppositories (as the base).
Smith Kline & French Laboratories, Philadelphia
T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1956.
Psychosomatic Medicine, Vol. 18, No. 1.

THORAZINE can allay the suffering caused by the pain of SEVERE BURSITIS
The ataractic, tranquilizing action of 'Thorazine' can reduce the anguish and suffering associated with bursitis.
'Thorazine' acts not by eliminating the pain, but by altering the patient's reaction -- enabling her to view her pain with a "serene detachment"
... Howell and his associates(1) reported: "Several of [our patients] expressed the feeling that ['Thorazine'] put a curtain between them and their pain,
so that whilst they were aware that the pain existed, they were not upset by it."
Smith Kline & French Laboratories, Philadelphia
1. Howell, T.H.; J.A.P., and Dietrich, M.: Practitioner 173:172.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1956.
Mental Hospitals, Vol. 7, No. 7. page 2.

in the child with a behavior disorder
THORAZINE*
reduces hyperactivity and aggressiveness
decreases anxiety and hostility
improves mood, behavior and sleeping habits
establishes accessibility to guidance or psychotherapy
increases amenability to supervision
facts to bear in mind --
Even though the dramatic calming effect of 'Thorazine' on belligerent, overactive children may give the impression of a cure,
simultaneous supportive counseling and guidance are necessary if lasting benefits are to be assured.
Adequate dosage for certain seriously disturbed youngsters will sometimes exceed 50-100 mg. t.i.d. 'Thorazine' should be
administered discriminately and, before prescribing, the physician should be fully conversant with the available literature.
'Thorazine' is available in ampuls, tablets and syrup (as the hydrochloride), and in suppositories (as the base).
Smith Kline & French Laboratories, Philadelphia
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1957.
Mental Hospitals, Vol. 8, No. 4.

Psychotherapy and Thorazine*...
a "combined therapy" most effective in the treatment of hyperkinetic emotionally disturbed children
Improvement was noted by Freed and Peifer in 21 of 25 hyperkinetic emotionally disturbed children who received 4 to 16 months of psychotherapy and 'Thorazine'.
Combativeness reduced
"Diminution in hyperactivity was the outstanding phenomenon. Combativeness was reduced considerably. There was a definite improvement in willingness to learn.
Trends toward increased emotional control were evidenced, although the basic personality seems unchanged."
Interpersonal relationships improved
'Thorazine', according to the authors, "dampens primitive fight-flight responses" without impairing consciousness and the learning process,
thereby improving interpersonal relationships.
Smith Kline & French Laboratories, Philadelphia
1. Freed, H., and Peifer, C.A.; Am. J. Psychiat. 113:22 (July) 1956.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1955.
Psychosomatic Medicine, Vol. 17, No. 2.

THORAZINE*
to control
ATTACKS OF MANIA
On administration of 'Thorazine', "attacks of mania
with accompanying elation, overactivity and delusions
of grandeur subside rather promptly...
This alone represents a therapeutic advance since
mania often resists shock therapies and is a very
exhausting condition for the patient, relatives and
hospital staff."
Kinross-Wright, V.: Postgrad. Med. 16:297 (Oct.) 1954.
Available in 10 mg., 25 mg., 50 mg., and 100 mg. tablets;
25 mg. (1 cc.) ampuls and 50 mg. (2 cc.) ampuls.
Information on 'Thorazine' is available on request.
Smith Kline & French Laboratories
1530 Spring Garden St., Philadelphia 1
*Trademark for S.K.F.'s brand of chlorpromazine hydrochloride.
Chemically it is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine hydrochloride.

Thorazine advertisement, 1960.
Mental Hospitals, Vol. 11, No. 5.

To control agitation -- a symptom that cuts across diagnostic categories
ThorazineŽ brand of chlorpromazine, a fundamental drug in psychiatry --
Because of its sedative effect, 'Thorazine' is especially useful in controlling hyperactivity, irritability and hostility.
And because 'Thorazine' calms without clouding consciousness, the patient on 'Thorazine' usually becomes
more sociable and more receptive to psychotherapy.
leaders in pharmaceutical research SMITH KLINE & FRENCH

Thorazine advertisement, 1956.
Psychosomatic Medicine, Vol. 18, No. 6.

to help you relieive
the severe emotional upset
of the menopausal patient
THORAZINE*
'Thorazine' can facilitate the over-all management of
your menopausal patient. Its unique, non-hypnotic
tranquilizing effect relieves anxiety, tension, agitated
depression and helps you to restore to the patient a
feeling of well-being and a sense of belonging.
'Thorazine' is available in ampuls, tablets and syrup
(as the hydrochloride), and in suppositories
(as the base).
for information write:
Smith Kline & French Laboratories, Philadelphia 1
*T.M. Reg. U.S. Pat Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1966.
Hospital & Community Psychiatry, Vol. 17, No. 10.

for severely psychotic patients where you want fast results
Assaultive, destructive, denudative patients who need effective tranquilizing and need it fast. Head-bangers, screamers, biters and other disruptive types.
Regressed patients with a time-hardened shield of apathy and withdrawal.
In a study of 36 highly psychotic patients... "Remarkable improvement... within... 1 to 3 days."
for patients who get side effects from high doses of single tranquilizers
Need greater therapeutic effect than low doses of one tranquilizer -- hypersensitive to possible side effects from high doses.
In 22 patients... "truly remarkable reduction of side effects."
for patients who need different drug effects at different times of day
'Stelazine' in the morning calms without sedating. 'Thorazine' at night reduces hyperactivity plus gently sedating. "Each drug providing a specific effect to good advantage."
for mental defectives who are behavior problems
Hostile aggressiveness (fighting, kicking, slapping); passive aggressiveness (stubbornness, obstructionism); filthy habits (excretory soiling, coprophagy).
60-year-old female... "first time... ever... employable."
Used in more than 250,000 patients ~ Thorazine brand of chlorpromazine & Stelazine brand of trifluoperazine combined
Precautions: For use in patients who are hospitalized or under adequate supervision. Potentiation of C.N.S. depressants may occur (reduce dosage of C.N.S. depressants
when used concomitantly.) Antiemetic effect may mask other conditions. Possibility of drowsiness should be borne in mind for patients who drive cars, etc.
In pregnancy, use only when necessary to the welfare of the patient. Use with caution in patients with angina or impaired cardiovasculary systems.
Prolonged administration of high doses may result in accumulative effects with severe C.N.S. or vasomotor symptoms.
Side effects: Occasionally dry mouth; nasal congestion; constipation; amenorrhea; mild fever; hypotensive effects, sometimes severe with I.M. administration;
epinephreine effects may be reversed; dermatological reactions; neuromuscular (extrapyramidal) symptoms (motor restlessness, dystonias, pseudo-parkinsonism) may occur
and, in rare instances, may persist; weight gain; miosis; lactation and moderate breast engorgement (in females on high dosages); insomnia; dizziness; muscular weakness;
anorexia; and less frequently jaundice. Rarely mydriasis; agranulocytosis; skin pigmentation, lenticular and corneal deposits (after prolonged substantial dosages).
Smith Kline & French Laboratories SKF

Thorazine advertisement, 1956.
Psychosomatic Medicine, Vol. 18, No. 2.

in many gastrointestinal disorders
THORAZINE* "would appear to be... tranquilizing agent of choice..."
in many gastrointestinal disorders... functional as well as secondary to organic disease such as spastic colon, peptic ulcer and
a variety of other conditions marked by pain and vomiting, 'Thorazine' has 3 advantages:
1. 'Thorazine' abolishes the emotional turbulence -- fear, excitation, anxiety, tension -- that adversely affects digestion and the digestive tract.
2. 'Thorazine' effectively controls the nausea and vomiting of gastrointestinal disorders.
3. 'Thorazine' has a mild atropine-like, inhibitory effect on gastric secretion and "would appear to be... tranquilizing agent of choice
when stimulation of gastric secretion is contraindicated."
'Thorazine' should be administered discriminately; and, before prescribing, the physician should be fully conversant with the available literature.
'Thorazine' is available as the hydrochloride in ampuls, tablets and syrup; and as the base in suppositories.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F. ~ Smith, Kline & French Laboratories, Philadelphia

Thorazine advertisement, 1956.
Psychosomatic Medicine, Vol. 18, No. 3.

in psoriasis --
THORAZINE*
"appears to be indicated... particularly in persons with emotional instability."
psoriasis -- "beneficially influenced" by Thorazine*
The ataractic, tranquilizing effect of 'Thorazine' can do so much to relieve the emotional stress that is so often a complicating or even a causative factor in many somatic conditions.
Reiss(1) observed that 12 out of 15 psoriatic patients "showed a reduction of the number of lesions" after 'Thorazine' therapy of 1 to 4 weeks.
He concluded that "the psoriatic process can be beneficially influenced" by 'Thorazine'.
1. Reiss, F. (New York City): Psoriasis and Stress, presented at International Medical Congress, Verona, Italy, Sept. 1, 1955.
'Thorazine' should be administered discriminately; and, before prescribing, the physician should be fully conversant with the available literature.
'Thorazine' is available as the hydrochloride in ampuls, tablets and syrup (as the hydrochloride) and in suppositories (as the base).
Smith, Kline & French Laboratories, Philadelphia
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1955.
Psychosomatic Medicine, Vol. 17, No. 5.

THORAZINE* in SCHIZOPHRENIA
"Our most encouraging results have occurred in chronic schizophrenics who were resistant to all psychiatric therapies,
including psychotherapy, intensive shock therapy, or did not maintain improvement after prefrontal lobotomy.
After they were placed on the 'Thorazine' program, 17 of the 27, or 63% of the shock treatment failures improved sufficiently to be discharged home."
Ford, H., and Jameson, G.K.: Paper presented at A.M.A. Clinical Meeting, Miami, Florida, Dec., 1954.
'Thorazine' Hydrochloride is available in 10 mg., 25 mg., 50 mg. and 100 mg. tablets; 25 mg. (1 cc.) and 50 mg. (2 cc.) ampuls; and syrup (10 mg./5 cc.).
Additional information on 'Thorazine' is available on request.
Smith, Kline & French Laboratories 1530 Spring Garden Street, Philadelphia 1
*T.M. Reg. U.S. Pat. Off. for S.K.F.'s brand of chlorpromazine.

Thorazine advertisement, circa 1957

Doctor, what can you do for Pop?
Deeply involved in the problem of the hostile, agitated senile are members of the family... and you, their physician.
In discussing the use of 'Thorazine', Pollack(1) observes:
"Older persons with such disorders can be treated at home by the general practitioner with much benefit and with great relief to the family."
With 'Thorazine', senile patients become calm, agreeable and sociable. They begin to eat and sleep better, often gain weight and improve physically.
for prompt control of the agitated, belligerent senile...
THORAZINE*
Ampuls for immediate effect -- carry them in your bag
Also available: Tablets, Syrup and Suppositories
Smith, Kline & French Laboratories, Philadelphia
1. Pollack, B.: Geriatrics 11:253 (June) 1956.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine. S.K.F.

Thorazine ad, circa 1959

for prompt and sustained relief from
severe mental and
emotional stress
THORAZINE* SPANSULE*capsules
chlorpromazine, S.K.F.
sustained release capsules, S.K.F.
30 mg. 75 mg. 150 mg. 200 mg. 300 mg.
Smith, Kline & French Laboratories
*T.M. Reg. U.S. Pat. Off.

Thorazine advertisements, 1955 & 1956.
Journal of Bone and Joint Surgery,
Vol. 37-A, No. 5, p. 13; No. 6, p. 21.
Vol. 38-A, No. 2, p. 25; No. 2, p. 25.

another New use of 'Thorazine'
in Surgery -- THORAZINE*
calms the apprehensive and anxious patient
facilitates induction and intubation
potentiates analgesics and anesthetics
controls nausea, vomiting, hiccups and
emergence excitement
a valuable adjuvant in surgical procedures
in surgery
THORAZINE*
calms the apprehensive and anxious patient
stops vomiting, retching and hiccups
reduces the need for narcotics and sedatives
lessens the amount of anesthetic required
controls emergence excitement
provides a smoother course four your surgical patient in surgery --
THORAZINE*
calms the apprehensive and anxious patient
facilitates induction and intubation
potentiates analgesics and anesthetics
controls nausea, vomiting, hiccups and
emergence excitement
"A measure of protection from shock is suggested
in a number of cases." -- Lear, Chiron and Pallin with THORAZINE* preoperatively --
"anxiety and apprehension give way to relaxation and calmness"
When added to premedication, 'THORAZINE':
1) Augments the action of anesthetics so that reduced doses of
these agents can be used to provide satisfactory anesthesia.
2) Decreases reflex irritability.
3) Markedly inhibits postoperative vomiting.
4) Reduces the need for postoperative narcotics and sedatives.
Smith, Kline & French Laboratories, Philadelphia 1
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1959
for prompt control of
nausea and vomiting
in children
THORAZINE* Syrup
and Suppositories
In the over 1,500,000 children in whom 'Thorazine' has been
used, jaundice or agranulocytosis has never been reported.
Smith, Kline & French Laboratories
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1962.
Psychosomatics, Vol. 3, No. 2.

You can't tell me anything new about ThorazineŽ.
You're right, Doctor. We can't tell you anything basically new about 'Thorazine' (brand of chlorpromazine).
Its actions and effects are well known. Its efficacy has been clearly demonstrated. And it has been found
to be relatively safe, even in long-term therapy.
This is why 'Thorazine' remains the first choice in many psychiatric conditions, and the standard against
which newer tranquilizing agents are inevitably compared. In eight years, the replacement for time-tested,
time-proven 'Thorazine' has not been found.
Are you using 'Thorazine' to full advantage in your practice, Doctor?
Quotation is a statement we often hear; photograph is professionally posed.
A reminder advertisement -- For prescribing information, please see PDR or available literature.
Smith, Kline & French Laboratories, Philadelphia ~ leaders in psychopharmaceutical research

Thorazine advertisement, 1956.
Mental Hospitals, Vol. 7, No. 8., p. 2.

"disturbed wards have virtually disappeared"
Many hospitals have found that
THORAZINE*
makes patients accessible and receptive to psychotherapy
reduces or eliminates the need for restraint and seclusion
improves ward morale
speeds release of hospitalized patients
reduces destruction of personal and hospital property
reduces need for shock therapy and lobotomy
increases capacity of hospital to serve more patients than ever before
'Thorazine' is available in ampuls, tablets and syrup (as the hydrochloride), and in suppositories (as the base).
Smith, Kline & French Laboratories, Philadelphia
1. Overholser, W.: in Chlorpromazine and Mental Health, Philadelphia, Lea & Febiger, 1955.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1957.
Mental Hospitals, Vol. 8, No. 2.

withdrawn, apathetic patients also can benefit from
THORAZINE*
Nondisturbed Psychotic Patients
Improved with 'Thorazine' Therapy
Although 'Thorazine' is considered specific for agitated and hyperactive patients, Rockmore et al. reported --
"... the greatest improvement [with 'Thorazine'] occurs among those patients who, before treatment
were passive, uncommunicative, asocial, and unconcerned about their personal appearance."
Smith, Kline & French Laboratories, Philadelphia
1. Rockmore, L.; Shatin, L., and Funk, I.D.: Psychiat. Quart. 30:189 (April) 1956.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1956.
Mental Hospitals, Vol. 7, No. 4.

THORAZINE*
helps to keep more patients out of mental hospitals
With 'Thorazine' "more patients will be released after shorter periods
of hospitalization and fewer patients will require re-hospitalization.
More patients can be treated in the community, at clinics or in the
psychiatrist's office without being hospitalized at all."
'Thorazine' is available as the hydrochloride in ampuls, tablets and syrup; and as the base in suppositories.
For information write:
Smith, Kline & French Laboratories, 1530 Spring Gardent Street, Phila. 1
1. Hoffman, J.L.: in Chlorpromazine and Mental Health, Philadelphia, Lea & Febiger, 1955.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F.

Thorazine advertisement, 1957.
Mental Hospitals, Vol. 8, No. 8.

EXTRA
All DAY Smith, Kline & French Laboratories, Philadelphia, Pa. ALL NIGHT
THORAZINE* SPANSULE** CAPSULES
S.K.F. ANNOUNCES ALL-DAY OR ALL-NIGHT 'THORAZINE' THERAPY WITH A SINGLE ORAL DOSE
New 'Thorazine' Spansule capsules offer the proven efficacy of 'Thorazine' plus the advantages of all-day or
all-night therapy with a single oral dose. Your patients will enjoy the convenience of only one or two doses daily.
There is little risk of forgotten doses and consequent medication-free intervals. For the discharged mental patient on
maintenance therapy, 'Thorazine' Spansule capsules will eliminate the trouble and embarrassment of taking tablets at work.
'Thorazine' Spansule capsules help hospital personnel save time in busy wards. Patients who require tablet medication
three or more times daily can obtain the same therapeutic benefits with only one or, at the most, two doses daily.
To give you optimum flexibility in selecting and adjusting dosages for your individual patients, 'Thorazine' Spansule
capsules are available in four strengths: 30 mg. 75 mg., 150 mg. and 200 mg.
Convenient Dosage Form ~ Thorazine's Usefulness Enhanced ~ Four Strengths Offered
In many cases, a single dose in the morning will achieve the desired response. When 24-hour therapeutic effect is
desired, the morning dose may be repeated in the late afternoon or evening.
Only one or two doses daily save time in busy wards where three or four "dosage rounds" with tablets were required.
*T.M. Reg. U.S. Pat. Off. for chlorpromazine, S.K.F. ~ *T.M. Reg. U.S. Pat. Off. for sustained release capsules, S.K.F.

Thorazine advertisement, 1955.
Mental Hospitals, Vol. 6, No. 12.

THORAZINE*
reduces need for electroshock therapy
For example, at Rochester Stte Hospital, New York, "most of
the electric shock in the hospital was suddenly abolished and
'Thorazine' was substituted... The number of patients receiving
electric shock has fallen from a former level of 300 to only 9."
Pollack, B.: M. Times 83:439 (May) 1955.
'Thorazine' Hydrochloride is available in 10 mg., 25 mg., 50 mg.
and 100 mg. tablets; 25 mg. (1cc.) and 50 mg. (2cc.) ampuls;
and syrup (10 mg./5cc.)
Additional information on 'Thorazine' is available on request.
Smith, Kline & French Laboratories, Philadelphia 1
Now, available to mental hospitals: 'Thorazine' 200 mg.
tablets -- for economy and convenience in treating
patients on the higher dosage regimens.
*T.M. Reg. U.S. Pat. Off. for S.K.F.'s brand of chlorpromazine.

Thorazine advertisement, 1967.
Hospital & Community Psychiatry, Vol. 18, No. 9.

Remember these? About 13 years ago, ThorazineŽ brand of chlorpromazine helped make them obsolete.
Even more important, it helped to eliminate or modify delusions and hallucinations, lessen confusion, and make the patient
more amenable to other forms of therapy.
In psychiatry, 'Thorazine' remains today's most widely prescribed ataractic.
Before prescribing, please see the complete prescribing information, including side effects reported with phenothiazine derivatives and symptoms and treatment of overdosage, in SK&F literature or PDR. The following is a brief precautionary statement.
Contraindications: Comatose states or the presence of large amounts of C.N.S. depressants. Precautions: Potentiation of C.N.S. depressants may occur (reduce dosage of such agents when used concomitantly). Antiemetic effect may mask signs of overdosage of toxic drugs or obscure diagnosis of other conditions. Administer in pregnancy only when necessary for patient's welfare. Possibility of drowsiness should be kept in mind for patients who drive cars, etc. Side Effects: Drowsiness; dry mouth; nasal congestion; constipation; amenorrhea; miosis; mild fever; weight gain; hypotensive effects, sometimes severe with I.M. administration; epinephrine effects may be reversed; dermatological reactions; parkinsonism-like symptoms on high dosages (in rare instances, may persist); lactation and moderate breast engorgement (in females on high dosages); and less frequently, cholestatic jaundice (use cautiously in patients with liver disease). Side effects occurring rarely include: mydriasis; agranulocytosis; skin pigmentation; lenticular and corneal deposits (after prolonged substantial doses). Available: Tablets -- 10 mg., 25 mg., 50 mg., 100 mg. and 200 mg. Ampuls -- 1cc. and 2cc. (25mg./cc). Multiple-dose Vials -- 10 cc. (25mg./cc). SpansuleŽ capsules -- 30 mg., 75 mg., 150 mg., 200 mg. and 300 mg. Concentrate -- 30 mg./cc.
Smith, Kline & French Laboratories, Philadelphia SK&F

Thorazine advertisement, 1968.
Hospital & Community Psychiatry Vol. 19, No. 4.

Profound calming... Stat.
ThorazineŽ brand of chlorpromazine In acute psychic disturbance * Alcoholic agitation, delirium and vomiting.
Before prescribing, see the complete prescribing information, including adverse effects reported with phenothiazine derivatives and
symptoms and treatment of overdosage, in SK&F literature or PDR. The following is a brief precautionary statement.
Contraindications: Comatose states or the presence of large amounts of C.N.S. depressants.
Precautions: Potentiation of C.N.S. depressants may occur (reduce dosage of such agents when used concomitantly). Antiemetic effect
may mask signs of overdosage of toxic drugs or obscure diagnosis of other conditions. Administer in pregnancy only when necessary
for patient's welfare. Possibility of drowsiness should be kept in mind for patients who drive cars, etc.
Adverse reactions: Drowsiness; dry mouth; nasal congestion; constipation and, on high dosages, adynamic ileus; amenorrhea; miosis;
mild fever; weight gain; hypotensive effects, sometimes severe with I.M. administration; epinephrine effects may be reversed;
dermatological reactions including photosensitivity (avoid undue exposure to the sun); extrapyramidal symptoms on high dosages
(in rare instances, may persist); lactation and moderate breast engorgement (in females on high dosages); and less frequently,
cholestatic jaundice (use cautiously in patients with liver disease). Adverse reactions occurring rarely, include: mydriasis;
agranulocytosis; skin pigmentation, epithelial keratopathy, lenticular and corneal deposits (after prolonged substantial doses).
Available: Tablets, 10 mg., 25 mg., 50 mg., 100 mg. and 200 mg.; SpansuleŽ capsules, 30 mg., 75 mg., 150 mg., 200 mg. and 300 mg.;
Injection, 25 mg./cc.; Syrup, 10 mg./5cc.; Concentrate, 30 mg./cc.
Š 1967, 1968 Smith, Kline & French Laboratories

Thorazine advertisement, 1955.
Mental Hosptials, Vol. 6, No. 2, p. 2.

S.K.F.'s Selective Neurologic Depressant
In Severe Excitement
THORAZINE*
'Thorazine' is "of unique value in the symptomatic control of
almost any kind of severe excitement. This includes catatonic
schizophrenia, schizoaffective conditions, epileptic clouded states,
agitation occurring in lobotomized patients immediately or
several months after surgery, and organic-toxic confusional states,
as frequently observed in uremic conditions and senile psychoses.
(Lehmann, H.E., and Hanrahan, G.E.: A.M.A. Arch. Neurol. &
Psychiat. 71:227 [Feb.] 1954)
Available in tablets and ampul solution for injection.
Additional information on 'Thorazine' available on request.
Smith, Kline & French Laboratories
1530 Spring Garden Street, Philadelphia 1
*Trademark for chlorpromazine hydrochloride, S.K.F.

Thorazine advertisement, 1961.
Mental Hospitals, Vol. 12, No. 10.

No other drug in psychiatry has achieved the lasting foundation that ThorazineŽ brand of chlorpromazine has in its seven years of clinical use
* effectiveness
* relative safety
* extensive documentation
A fundamental drug in psychiatry.
Smith, Kline & French Laboratories, Philadelphia
leaders in psychopharmaceutical research

ADULT INDICATIONS AND DOSAGE
Dosage should always be adjusted to the response of the individual and the severity of the condition. It is important to increase dosage until symptoms are controlled or side effects become excessively troublesome. SIDE EFFECTS
The drowsiness caused by 'Thorazine' may be unwanted in some patients. It is usually mild to moderate and disappears after the first or second week of therapy. If, however, drowsiness is troublesome, it can usually be controlled by lowering the dosage or by administering small amounts of dextro amphetamine.
Other side effects that have been reported occasionally are dryness of the mouth, nasal congestion, some constipation, miosis in a few patients and, very rarely, mydriasis.
Mild fever (99 F.) may occur occasionally during the first days of therapy with large intramuscular doses.
During 'Thorazine' therapy some patients have an increased appetite and gain weight. Usually these patients reach a plateau beyond which they do not gain further weight.
Causes of vomiting: The physician should always bear in mind that the antiemetic effect of 'Thorazine' may mask signs of overdosage of toxic drugs and may obscure diagnosis of conditions such as intestinal obstruction and brain tumor.
Extrapyramidal Symptoms: With very large doses of 'Thorazine", as frequently used in psychiatric cases over long periods, there have been a few patients who have exhibited extrapyramidal symptoms which closely resemble parkinsonism. Such symptoms are reversible and usually disappear within a short time after the dosage has been decreased or the drug withdrawn. These symptoms can also be controlled by the concomitant administration of standard anti-parkinsonism agents.
Before prescribing 'Thorazine' in any indication other than those given here, the physician should be familiar with dosage, side effects, cautions and contraindications for such indications. This information is available in: ThorazineŽ Reference Manual and Physician's Desk Reference.

Thorazine advertisement, 1955.
Psychosomatic Medicine, Vol. 17, No. 6.

Thorazine* a major advance in Psychiatric Treatment
'Thorazine' is useful in controlling anxiety tension, agitation
confusion, delirium, or hostility, whether occurring in schizo-
phrenic, manic-depressive, toxic, or functional states.
"There is no evidence that large doses [of 'Thorazine'] impair
higher mental functions as is the case with sedatives and central
nervous depressants... Intelligence, memory and judgment are
intact, indeed are often strikingly improved in most psychotic
patients... As much as 2000 mg. a day [of 'Thorazine'] has been
given though the average requirement is about 400 to 600 mg. per day."
Kinross-Wright, V.: Postgrad. Med. 16:297 (Oct.) 1954.
'Thorazine' Hydrochloride is available in 10 mg., 25 mg., 50 mg. and
100 mg. tablets; 25 mg. (1 cc.) and 50 mg. (2 cc.) ampuls; and
syrup (10 mg./5 cc.). Additional information on 'Thorazine' is available on request.
Smith Kline & French Laboratories 1530 Spring Garden St., Philadelphia 1
*Trademark for S.K.F.'s brand of chlorpromazine.
Chemically it is 10-(3-dimethylaminopropyl)-2-chlorphenothiazine.

Thorazine advertisement, 1977.
Hospital & Community Psychiatry, Vol. 28, No. 1.

Basic tool of primitive psychiatry
Herbalist's staff (opa osanyin), with birds (wrought iron), Yoruba tribe, Nigeria. 21 inches.
This staff is topped by a circle to which 16 small birds (a magical number) are attached.
The single bird in the middle symbolizes the witch who causes sickness or death.
The staff is placed next to the shrine of Osanyin (the god of the herbalist), along with
eggs and kola, to neutralize the witch's evil spirit. Sometimes the staff is also placed
next to the bed of a sick person to chase away the disease-causing spirit.
From the collection of the Segy Gallery, New York City. Reproduced with permission.
Basic tool of modern psychiatry
ThorazineŽ brand of chlorpromazine
* 'Thorazine' effectively controls psychotic symptoms
* Especially useful in agitated, violent or anxious schizophrenic patients
* Unsurpassed clinical experience
* 18 convenient dosage forms and strengths
Breaks down schizophrenic barriers
Š 1967, 1968, 1969 SmithKline Corporation
[Warnings include]
Use in pregnancy only when essential. There are reported instances of jaundice or prolonged
extrapyramidal signs in newborn whose mother had received chlorpormazine.
[Adverse reactions include]
neuromuscular (extrapyramidal) reactions; pseudo-parkinsonism, motor restlessness, dystonias,
persistent tardive dyskinesia, hyperreflexia in the newborn.

Thorazine advertisement, 1975.
Hospital & Community Psychiatry, Vol. 26, No. 7.

Basic tools of primitive psychiatry
Kondi: Incarnation of Ndoki, an evil spirit which causes disease
Wish-projection "causes" illness when a nail is driven into the statue.
Also used to "drive out" an illness.
Bakongo, Zaire.
Mask: Represents the spirit of the underworld.
Used by the Ekpo male society, which honors dead ancestors and enforces the law.
Anang Ibibio, Nigeria.
Objects from the collection of the Segy Gallery, New York City. Basic tool of Western psychiatry
ThorazineŽ brand of chlorpromazine
* 'Thorazine' controls psychotic symptoms
* Especially useful in agitated, violent or anxious schizophrenic patients
* Unsurpassed clinical experience
* 18 convenient dosage forms and strengths
Effective control of psychotic agitation
Š 1967, 1968, 1969 SmithKline Corporation
[Warnings include]
Use in pregnancy only when essential. There are reported instances of jaundice or prolonged
extrapyramidal signs in newborn whose mother had received chlorpormazine.
[Adverse reactions include]
neuromuscular (extrapyramidal) reactions; pseudo-parkinsonism, motor restlessness,
dystonias, persistent tardive dyskinesia, hyperreflexia in the newborn.

Thorazine advertisement, 1973.
Hospital & Community Psychiatry, Vol. 24, No. 5.

HELPS KEEP THE REAL IN REALITY
THORAZINEŽ brand of CHLORPROMAZINE
Effective Management of Psychotic Symptoms
* Calms hyperactive behavior
* Controls hostility
* Decreases delusions, auditory and visual hallucinations
* Allays underlying fear, anxiety and tension
* Lessens unusual thought content, paranoid ideation
* Reduces emotional withdrawal
Š 1967, 1968, 1969 Smith Kline & French Laboratories
[Warnings include]
Use in pregnancy only when essential. There are reported instances of jaundice or
prolonged extrapyramidal signs in newborn whose mother had received chlorpormazine.
[Adverse reactions include]
neuromuscular (extrapyramidal) reactions; pseudo-parkinsonism, motor restlessness,
dystonias, persistent tardive dyskinesia, hyperreflexia in the newborn.

Thorazine advertisement, 1982.
Hospital & Community Psychiatry, Vol. 33, No. 6.

BEFORE THE REVOLUTION
Tortured minds and shackled limbs -- common conditions from an era past. The era before the introduction of 'Thorazine', an event that was to revolutionize psychiatric care.
Back in 1954, 'Thorazine' was notable for its effective control of the manifestations of psychosis, for increasing patient accessibility to psychotherapy, for helping restore large numbers of patients to productive lives in the community.
Today, 28 years later, it still is.
THORAZINEŽ brand of chlorpromazine.
From SK&F, pioneers in psychopharmacology. Indications: For the management of manifestations of psychotic disorders. To control the manifestations of the manic type of manic-depressive illness. For the treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability and poor frustration tolerance.
Based on a review of this drug by the National Academy of Sciences -- National Research Council and/or other information, FDA has classified the other indication as follows.
Possibly effective For control of excessive anxiety, tension and agitation as seen in neuroses
Final classification of the less-than-effective indication requires further investigation
[Warnings include]
The possibility of extrapyramidal reactions from chlorpromazine may confuse the diagnosis of Reye's syndrome or other encephalopathy. Therefore avoid use in children or adolescents with suspected Reye's syndrome.
[Adverse reactions include]
neuromuscular (extrapyramidal) reactions; pseudo-parkinsonism, motor restlessness, dystonias, persistent tardive dyskinesia.
Smith Kline &French Laboratories Philadelphia, Pa. Š SmithKline Corporation, 1982

Thorazine advertisement, 1959.
Mental Hospitals, Vol. 10, No. 7.

to restore them to their senses
"Surprise Bath" used in colonial times to "restore the distracted to their senses."
Original wood engraving by John De Pol.
Less than 200 years ago, the mentally ill were bled, purged, beaten and sometimes nearly drowned in efforts to
restore them to their senses. The treatment of mental illness has progressed far beyond methods such as these.
One of the major advances in psychiatry has come through chemotherapy -- now an important factor
in the treatment of mental illness, pioneered and developed with 'Thorazine'.
The importance of 'Thorazine' is twofold:
(1) its continued widespread use has established it as a fundamental drug that can be used with confidence and
(2) it has led S.K.F. to the development of related drugs which offer the psychiatrist the opportunities
to help an even greater number of patients.
THORAZINE* chlorpromazine, S.K.F. Smith Kline & French Laboratories *T.M. U.S. Pat. Off.