Teething
Child Health
Histamine is one of the few central nervous system
neurotransmitters found to cause consistent blood-brain barrier opening. The
earlier literature was unclear, but studies of pial vessels and cultured
endothelium reveal increased permeability mediated by H2 receptors and elevation
of [Ca2+]i and an H1 receptor-mediated reduction in permeability coupled to an
elevation of cAMP. /// During the intra-osseous phase of tooth eruption, the
proportional increase in the number of mast cells in the lamina propria and
osteoclasts indicates that mast cells could be involved in the bone resorption
and, thereby, in the establishment of the eruptive pathway. Activated mast cells
degranulate and thereby release several inflammatory mediators and growth
factors, including histamine{References:
http://www.ncbi.nlm.nih.gov/pubmed/10696506;
http://www.ncbi.nlm.nih.gov/pubmed/7982064;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687937;
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7580.2010.01249.x/full