|ISSELS FOUNDATION INC.
It is the purpose of the
ISSELS FOUNDATION INC. to inform about the potential of
comprehensive immunobiological treatment of cancer and chronic
Josef M. Issels,
Holistic Comprehensive Immunotherapy
For More Info: 1-888-DR ISSELS (US
The Issels Foundation, Inc. can be reached by e-mail at
Click on the email link to send a message.
Josef M. Issels, MD, has become internationally known for his
remarkable rate of complete long-term remissions of "incurable
cancers" in patients who had exhausted all standard treatments, such
as advanced cancers of the breast, uterus, prostate, colon, liver,
lung, brain, sarcomas, lymphomas, and leukemias. After completion of
Dr. Issels' treatment, these patients remained cancer free for up to
45 years, leading normal healthy lives. Dr. Issels' treatment also
significantly reduced the incidence of recurrent cancer after
surgery, radiation, and chemotherapy, thereby considerably improving
chart describing the development of cancer.
Holistic comprehensive immunotherapy was able to reverse chronic
degenerative diseases such as arthritis, lupus, Grave's disease,
Sjoegren's syndrome, asthma, etc.
In 1951 Dr. Issels founded the first hospital in Europe for
comprehensive immunotherapy of cancer. He was the Medical Director
and Director of Research. In 1970 the hospital was enlarged from 80
to 120 patient beds. It contained extensive research facilities
including immunological and microbiological laboratories. The
Hospital's programs included research on tumor vaccines, mycoplasma
and bacterial vaccines inducing fever, hyperthemia, etc. Ninety
percent of the patients treated at the hospital had exhausted
standard cancer treatment.
From 1981 until 1987, Dr. Issels served as an expert member of,
and advisor to, the Commission of the German Federal Government in
the Fight Against Cancer.
Dr. Issels presented many papers to national and international
medical congresses and within programs of continuing education. He
also published three monographs.
Dr. Issels' Concept of the
Development of Cancer and Its Treatment
Dr. Issels' treatment is based on the concept that malignant
tumors do not develop in a healthy body with intact defense and
repair functions. They present in a specific internal environment
which promotes their growth. This environment develops over a period
of time due to multiple causes and conditions which persist and
remain chronically active even after removal of the tumor (by
surgery, radiation, and/or chemotherapy). These remaining causes are
responsible for the formation of new tumors which occur after local
treatment in every second cancer patient, according to World
Therefore, Dr. Issels' treatment program places equal importance
on the removal of the tumor itself and on the
causes and conditions leading to the body's tendency to develop
Dr. Issels' holistic comprehensive immunotherapy is based on the
Pre-and postnatal endogenous and exogenous causal factors (I) can
lead by mutagenic, toxic, sensitizing or neural effects via the
transit mesenchyme to secondary damages to organs and organ systems
and so to functional disturbances of the neural, hormonal, excretory
and defense systems (II).
These secondary damages and especially the disturbance of the
detoxification system deteriorate the internal environment , or
"milieu", and can lead to complex metabolic disturbances which are
common to all chronic disease and cancer.
Further constant influence of the causal factors and the
persistence of secondary damages can produce a functional imbalance
and deteriorate the defense and repair mechanisms. Depending on
inherited constitution and disposition, this can develop into a
chronic degenerative disease and a "tumor-milieu," (III) the ideal
medium for cancer cells and cancer micro-organisms to grow. The body
has acquired the tendency to produce malignant tumors.
With the manifestation of the tumor (IV), the cancer disease
enters the recognizable phase. At this time, conventional cancer
treatment begins with the weapons directed against the cancer tumor
and its symptoms (V).
According to the concept that cancer starts as a locally confined
growth, all measures concentrated on the tumor alone seem causal and
Treating the tumor alone is not treating the condition that is
producing it: the underlying cancer disease. Consequently, there is
a high rate of relapse.
According to the comprehensive concept, however, cancer is
considered a systemic disease from the onset and the tumor as its
late stage symptom.
Following this concept Dr. Issels' therapy has two lines of
approach which are of equal importance and complement each other.
- A non-specific basic therapy aiming to eliminate the causal
factors, repair damages of the early stages, normalize the
internal milieu, and restore the immune and repair functions.
- A specific therapy directed against the tumor itself, such
as surgery, radiation, chemo/hormone therapy, hyperthermia, and
The non-specific basic therapy corresponds with the pathological
path leading to the immuno-insufficiency and the cancer disease. It
is modified to suit the individual patient's needs. It consists of:
- Elimination of causal factors, such as head foci of
infection including dental, alveolar and tonsillar foci,
malnutrition, abnormal intestinal flora, fields of disturbance,
physical and chemical exogenous factors, endogenous and
- Desensitization of the organism which has been sensitized by
causal factors by administration of autohemolysates and
- Treatment of secondary damages, metabolic disturbances, the
impaired detoxification and the resulting defense weakness, by
general measures, such as hyperpyrexia or fever therapy, oxygen
therapy, enzyme-therapy, neural-therapy and organ-therapy, as
well as substitution according to individual requirements.
The basic therapy is a long-term one without any toxic side
effects and aims at the regeneration of the "big resistance," which
comprises all the defense zones:
- The extracorporal zone consisting of the physiological
obligatory microflora which is responsible for the basic
immunity of the organism.
- The epithelial zone consisting of all epithelial surfaces
which performs defense, filtration, excretion and absorption.
- The lympho-reticulo defense zone which performs the
important tasks of phagocytosis, antibody production and
detoxification. On this zone, immunotherapy is mainly centered
- The reticulo-histiocytary zone, which has been neglected in
cancer therapy and research, is the pluripotent mesenchyme
embracing almost half of the body weight. It is of great
importance to all defensive processes with its various
- the stemcell function;
- the transit function that intervenes between all nerves,
organ cells, blood, lymphatic and intestinal cells;
- the homeostatic function;
- the defense, detoxification and storage functions.
These defense zones are successive, are closely interrelated and
are under neuro-hormonal control.
The blockade of only one function of one of these zones for
example of the excretion, or even the blockade of the control system
such as the autonomous nervous system may contribute indirectly to a
lowering of the defense potential. During treatment, it was
repeatedly observed that by the elimination of head foci, or with a
fever therapy a blockade of the neuro-hormonal functions was broken.
Even in an advanced state of malignant disease an immune reaction
with complete tumor remission can be reached.
Holistic comprehensive immunotherapy opens up the following
A system of monitoring regulative functions on a day by day basis is
an essential tool to determine the effectiveness of the treatment.
Therefore, during his 40 years of experience at the sickbed, Dr.
Issels developed a system to enable optimum individualized
application of the treatment modalities.
- Treatment of cancer of all kinds and stages offering a
considerable chance of recovery even for patients in advanced
stages who have exhausted all standard treatments.
- Follow-up treatment to prevent recurrence after standard
cancer therapy through restoration of the patient's defense and
repair functions (the World rate of recurrence is 50%).
- Nontoxic preventive treatment for patients at risk, and
those with precancerous diseases.
- Preparatory treatment prior to surgery, radiation, and
chemotherapy to reduce the risk of complications and in
qualified cases, to render inoperable tumors operable.
- Treatment of chronic degenerative diseases which are
untreatable by standard methods.
For more information on Dr. Issels'
work in the field of cancer and chronic diseases, please call toll
free from the USA and Canada: 1-888-DR ISSELS (1-888-374-7735). From
other countries: 760-929-7155.
The Issels Foundation Inc. can be reached by e-mail at
Click on the link to send a message.
Josef M. Issels, MD
Nov. 21, 1907 - Feb. 11, 1998
Josef M. Issels, M.D. reported in "Immunotherapy in
Progressive Metastatic Cancer, A Fifteen Year Survival
Follow-up" Clinical Trials Journal (London) 1970. 7, NO.
3, pp. 357-366, that of 370 patients with various
cancers who were given immunological treatment shortly
after surgery or irradiation, 322 (87%) were alive and
well after five years without relapse or detectable
metastases. A restoration of the immune functions can
reduce the incidence of relapse from about 50% (World
Statistic) to 13% by combined conventional treatments
and comprehensive immunotherapy.
An independent statistical study by A.G. Audier,
M.D., University of Leiden, Holland "Immunotherapie
Metastasierender Malignome" Die Medizinische 1959, NO.
40, pp. 1860-64, reported a 16.6% cure rate of
histologically verified metastatic malignomas by the
Issels comprehensive immunotherapy. The study comprised
252 patients with various cancers after all conventional
methods were exhausted (World wide cure rate is 2%).
John Anderson, M.D., Teaching Professor at King's
College Hospital, London, reported 17% cures of
histologically verified metastatic malignomas by the
Issels comprehensive immunotherapy. The independent
randomized study comprised 570 patients with various
cancers after all conventional methods were exhausted
(General Practitioner, March 1971, pp. 15-16, London).
The charts on the left highlight documented
results of the Issels comprehensive immunotherapy.