Salbutamol "In the 1960s, an increase in asthma
deaths in Britain coincided with the increase in sales of isoprenaline inhalers.
The circumstantial evidence implicated the high-strength isoprenaline (known as
isoprenaline-forte) used in the inhalers. There was also evidence that some
patients had used it more frequently despite worsening asthma, although the
exact cause of the deaths remains unknown."