July 20, 2001
U.S. IMMUNIZATION NEWS
Downes
KA, Domen RE, McCarron KF, Bringelsen KA. Acute autoimmune hemolytic
anemia following DTP vaccination: report of a fatal case and review of the literature. Clin Pediatr (Phila). 2001 Jun;40(6):355-8. Review. No abstract available.PMID:
11824181 [PubMed - indexed for MEDLINE]
"Acute Autoimmune Hemolytic Anemia Following DTP Vaccination: Report of a
Fatal Case and Review of the Literature"
Clinical Pediatrics (06/01) Vol. 40, No. 6, P. 355; Downes, Katharine A.; Domen, Ronald
E.; McCarron, Karen F.
This study reviews the case of an African-American female infant who experienced severe
anemia and a drop in hemoglobin levels and was admitted to the hospital in an unresponsive
condition at just four months of age. Admitted to the hospital between her
fifth and sixth week, the infant exhibited unusual irritability and was tested for
possible meningitis or sepsis, and then was empirically treated with a combination of
ceftaxime and ampicillin and released in good health. At four months of age,
the child was given her second doses of the oral polio virus, hepatitis B, and diphtheria,
tetanus, and pertussis (DTP) vaccines, and within four days she exhibited lethargy, a low
level fever, and lack of appetite. She was unresponsive when admitted to the
hospital three days later, suffering from severe anemia and low hemoglobin levels.
Tests for Haemophilus influenza, Streptococcus pneumoniae, and Neiseria meningitidis were
negative or did not appear conclusively as cause or contributor to the current
condition. The infant continued to experience severe hemolysis and died 41 hours
after admission. Although the study could not prove it conclusively, by eliminating other
causes of autoimmune hemolytic anemia (AIHA), the researchers suggest that, in this case,
there is "a causal relationship to the second DTP vaccination." A 1992
report from the Institute of Medicine concluded, however, that there is insufficient
evidence of either the presence or absence of such a connection.