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Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years

Authors: Carolyn Gallagher a; Melody Goodman a
Affiliation:   a Graduate Program in Public Health, Stony Brook University Medical Center, Health Sciences Center, New York, USA
DOI: 10.1080/02772240701806501
Publication Frequency: 8 issues per year
Published in: journal Toxicological & Environmental Chemistry, Volume 90, Issue 5 September 2008 , pages 997 - 1008
Formats available: HTML (English) : PDF (English)
Previously published as: Toxicological & Environmental Chemistry Reviews (0092-9867) until 1980



This study investigated the association between vaccination with the Hepatitis B triple series vaccine prior to 2000 and developmental disability in children aged 1-9 years (n = 1824), proxied by parental report that their child receives early intervention or special education services (EIS). National Health and Nutrition Examination Survey 1999-2000 data were analyzed and adjusted for survey design by Taylor Linearization using SAS version 9.1 software, with SAS callable SUDAAN version 9.0.1. The odds of receiving EIS were approximately nine times as great for vaccinated boys (n = 46) as for unvaccinated boys (n = 7), after adjustment for confounders. This study found statistically significant evidence to suggest that boys in United States who were vaccinated with the triple series Hepatitis B vaccine, during the time period in which vaccines were manufactured with thimerosal, were more susceptible to developmental disability than were unvaccinated boys.