Ophthalmological and Biological Features of the Oculorespiratory Syndrome after Influenza Vaccination


Marie JoseŽe Fredette, Gaston De Serres, and Mario Malenfant Centre Hospitalier Universitaire de Laval (CHUL) Research Center, Centre Hospitalier Universitaire de QueŽbec, CHUL, Laval University, Ste-Foy, and 2Institut National de SanteŽ Publique du QueŽbec, QueŽbec, Canada

During the autumn of 2000, oculorespiratory syndrome (ORS),
a new adverse event associated with influenza vaccination, was
identified in Canada [1–5]. The clinical case definition required
that, within 24 h after influenza vaccination, the patient develop
1 of the following symptoms: bilateral red eyes, respiratory
symptoms (i.e., cough, wheezing, difficulty breathing, difficulty
swallowing, hoarseness, chest tightness, and/or sore throat), and
facial edema [5]. We report the findings for 6 patients with
ORS with red eyes who had a complete ophthalmological examination
and a standardized laboratory blood investigation.