Rabies vaccine adverse reactions
Citations

Arega D, Zenebe G. Peripheral neuropathy following administration of nerve tissue antirabies vaccine.Ethiop Med J. 1999 Oct;37(4):269-73.PMID: 11961878 [PubMed - indexed for MEDLINE]

Ahasan HA, Chowdhury MA, Azhar MA, Rafiqueuddin AK. Neuroparalytic complications after anti-rabies vaccine (inactivated nervous tissue vaccine)Trop Doct. 1995 Apr;25(2):94. No abstract available.PMID: 7778211 [PubMed - indexed for MEDLINE]

Arch. Neurol 35: 693, 1978. The authors describe a multiple sclerosis like illness occurring 4 years after rabies immunization. It references a paper describing similar cases presenting 2-20 years after immunization with the rabies vaccine.

Alvord EC Jr, et al. The causes of the syndromes of Landry (1859) and of Guillain, Barre and Strohl (1916). Rev Neurol (Paris). 1987;143(8-9):571-9. PMID: 2445014; UI: 88042403.
The syndromes of Landry (1859) and of Guillain, Barre and Strohl (1916) differ clinically and pathologically, the latter a purely peripheral neuritis and the former a mixture of transverse myelitis and facial neuritis. Each can be caused by many different factors, including 1) direct infection by wild or attenuated rabies virus, 2) direct auto-sensitization by myelin antigens in the vaccine....

Agulleiro Moreira JM, et al. [See Related Articles] [Neurological manifestations of anti-rabies vaccination]. Prensa Med Argent. 1968 Aug 23;55(26):1262-4. Spanish. No abstract available.PMID: 5709495; UI: 69109930.
Bahri F, et al. [See Related Articles] [Neurological complications in adults following rabies vaccine prepared from animal brains]. Presse Med. 1996 Mar 23;25(10):491-3. French. PMID: 8685108; UI: 96306396. OBJECTIVES: Despite well-known neurological complications, post-exposure semple-type rabies vaccine is still used in Tunisia. We retrospectively studied neurological manifestations following post-exposure rabies vaccine. METHODS: Over a 3-year period, semple-type phenol inactivated lamb nerve tissue vaccine (Pasteur Institute, Tunis) was given to 1392 adults after exposure to rabies. RESULTS: The frequency of neurological complications was 1/200. Seven patients presented complications 4 to 14 days after the first vaccine injection (median 11 days). Central nervous system manifestations occurred in all 7 patients with peripheral neuropathy in 5. Manifestations were meningoradiculitis (n = 3), meningomyeloradiculitis (n = 2), meningomyelitis (n = 1) and myelitis (n = 1). No vaccine-associated death occurred, but one patient suffered persistant paraplegia. CONCLUSION: Semple-type adult animal nerve tissue vaccine produces an unacceptable rate of severe post-vaccinal neurological complications in adults. Human diploid cell rabies vaccine should be used for post-exposure rabies vaccination.
Boe E, et al. Guillain-Barre syndrome after vaccination with human diploid cell rabies vaccine. Scand J Infect Dis. 1980;12(3):231-2. PMID: 7001615; UI: 81056244.[See Related Articles]

Britton DE, Houff SA, Eiben RM.Possible interactions between rabies vaccination and a progressive degenerative CNS disease.Arch Neurol. 1978 Oct;35(10):693. No abstract available.PMID: 29594 [PubMed - indexed for MEDLINE]

Bernard KW, Smith PW, Kader FJ, Moran MJ. Neuroparalytic illness and human diploid cell rabies vaccine. JAMA. 1982 Dec 17;248(23):3136-8. No abstract available. PMID: 7143690 [PubMed - indexed for MEDLINE]

Cabrera J, et al. Unusual features of the Guillain-Barre syndrome after rabies vaccine prepared in suckling mouse brain. J Neurol Sci. 1987 Nov;81(2-3):239-45. PMID: 3694230; UI: 88089727.[See Related Articles]

Chakravarty A. Neurologic illness following post-exposure prophylaxis with purifiled chick embryo cell antirabiesvaccine. J Assoc Physicians India. 2001 Sep;49:927-8.PMID: 11837768 [PubMed - indexed for MEDLINE]

Chaleomchan W, et al. Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases. J Neurol Sci. 1990 May;96(2-3):143-51. PMID: 2376746; UI: 90330972.

Consoloni E, Cartei MA, Ioppoli C, Fonte F. [Neuropathological complications of rabies vaccination: a case with involvement of the facial nerve]Riv Neurol. 1979 Jan-Feb;49(1):53-61. Italian. No abstract available.PMID: 451398 [PubMed - indexed for MEDLINE]

Dreesen DW, Bernard KW, Parker RA, Deutsch AJ, Brown J. Immune complex-like disease in 23 persons following a booster dose of rabies human diploid cell vaccine. Vaccine. 1986 Mar;4(1):45-9. PMID: 2938356 [PubMed - indexed for MEDLINE]

Dano P, et al. [See Related Articles]
Dubielzig RR, et al. [See Related Articles] Myofibroblastic sarcoma originating at the site of rabies vaccination in a cat. J Vet Diagn Invest. 1993 Oct;5(4):637-8. No abstract available.PMID: 8286472; UI: 94114633.
Ercegovac D, et al. [See Related Articles] [Onset of paralysis after vaccination against rabies]. Srp Arh Celok Lek. 1983 Apr;111(4):429-36. Serbo-Croatian (Cyrillic). No abstract available.PMID: 6665603; UI: 84121585.
Hemachudha T, et al.Immunologic studies of rabies vaccination-induced Guillain-Barre syndrome. Neurology. 1988 Mar;38(3):375-8. PMID: 2450302; UI: 88157125 Patients with Guillain-Barre syndrome (GBS) induced by rabies vaccines prepared from either suckling mouse brain (SMB) or mature sheep brain (Semple vaccine) and patients with sporadic, idiopathic GBS were studied for antibody to myelin basic protein (MBP), P2 protein, and Schwann cells. Sera from all four Semple vaccine- and one of five SMB vaccine-induced GBS patients, but none of the sporadic GBS patients, had antibody to MBP. Sera from Semple vaccinees also had antibody to fixed, transformed Schwann cells, but similar amounts of antibody were found in sera from Semple vaccinees with CNS complications and with minor non-neurologic complications, suggesting that this antibody was not specifically linked to the development of polyneuritis. None of the sera had detectable antibody to P2 protein. We conclude that patients with GBS constitute a heterogeneous population and that different target antigens may serve as a focus for this presumed autoimmune disease.

Hemachudha T, et al. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. N Engl J Med. 1987 Feb 12;316(7):369-74. PMID: 2433582; UI: 87115665[See Related Articles]

Kowal P. [See Related Articles] [Neurological complications after vaccination against rabies as exemplified by 4 cases from Poznan province]. Neurol Neurochir Pol. 1986 Mar-Apr;20(2):132-6. Polish. PMID: 2877405; UI: 87039603.

The author reports 4 cases of neurological complications following vaccination with cerebral-type lyophilized vaccine. The cases were observed in the Province of Poznan in the period from January to April 1984, and the patients were men aged 41 to 60 years with various clinical syndromes: Landry's ascending paralysis, polyradiculoneuritis, polyneuritis and encephalopolyradiculoneuritis. The high frequency of these complications (about 3%) might have been due to the high susceptibility of the vaccinated population, or to technical errors in the production of the vaccine leading to obtaining of a vaccine bath with a high immunoallergogenicity which could trigger off the complication in persons with individual predisposition.

Kovacs F, et al. [See Related Articles] [Neurologic complications from rabies vaccination]. Orv Hetil. 1968 Oct 13;109(41):2264-6. Hungarian. No abstract available.PMID: 5715141; UI: 69132332.
Kollmannsberger A. [See Related Articles] [Neurological complications following rabies vaccination]. Munch Med Wochenschr. 1966 Feb 4;108(5):259-62. German. No abstract available.PMID: 4383433; UI: 68047126.
Kuwert E, et al. [See Related Articles] [Neurological complications following rabies vaccination]. Med Klin. 1968 Aug 23;63(34):1326-8. Review. German. No abstract available.PMID: 4878778; UI: 69008466.
Kulik DM. [See Related Articles] [Complications due to antirabies vaccinations]. Sov Med. 1965 Apr;28(4):89-92. Russian. No abstract available.PMID: 5866348; UI: 66108610.

Knittel T, et al. Guillain-Barre syndrome and human diploid cell rabies vaccine. Lancet. 1989 Jun 10;1(8650):1334-5. No abstract available.PMID: 2566866; UI: 89260830.

Kreiner R, et al. [Encephalitis after rabies vaccination]. Psychiatr Neurol Med Psychol (Leipz). 1971 Sep;23(9):532-6. German. No abstract available.PMID: 4403287; UI: 72258327.

Larghi OP, Varela-Diaz VM, Soto E, Imas B, Cuba-Caparo A, Fuenzalida E. Laboratory investigations on neuroparalytic accidents associated with suckling mouse brain rabies vaccine. III. -- Preservation of vaccine potency after elimination of murine brain myelin by centrifugation.Ann Microbiol (Paris). 1976 Nov-Dec;127B(4):567-72.PMID: 1023791 [PubMed - indexed for MEDLINE]

(Luby JP; Ann Intern Med, 1974 Sep) Letter: Adverse reaction to duck embryo rabies vaccine.

Lery L, Gaillard L, Delphin D. [Benign neurologic accident following anti-rabies vaccination. Unforeseen clinical and biological aspects]Arch Fr Pediatr. 1975 Jun-Jul;32(6):563-7. French.PMID: 241305 [PubMed - indexed for MEDLINE]

Mittal HS, et al. Brainstem encephalopathy following antirabic vaccination. A case report. J Postgrad Med. 1971 Oct;17(4):184-6. No abstract available.PMID: 4400983; UI: 72131524.

Manghani DK, et al. Pleomorphism of fine structure of rabies virus in human and experimental brain. J Neurol Sci. 1986 Sep;75(2):181-93. PMID: 3760910; UI: 87010723.
Identification of the Negri bodies in the brain of an 8-year-old boy who died 8 days after a paralytic illness and 20 days after a dog bite, and who had received 9 injections of Semple's anti-rabies vaccine, provided evidence that he died of acute rabies encephalitis and not of post-vaccinal allergic encephalomyelitis. The Negri bodies in the human subject and those seen in the inoculated mouse differed in their morphological structure: the former consisted of a matrix of very fine granular material bearing larger granules or strands of higher electron-density resembling nucleic acids and representing products of host cell-virus interaction; and the latter showed better defined areas of granular matrix containing tubular, bullet-shaped and elongated forms of viral structures, and nucleocapsids or capsule-deficient cores, representing the virions, emerging from them. Fine structural examination of the patient's brain and of the inoculated mouse has provided evidence of the pleomorphism of the Negri bodies and the various stages of formation of viral material and virions in them, the animal alone showing the mature virions of rabies, and proving the infectivity of the Negri bodies of the human brain. (Emphasis added)

Murthy JM. [See Related Articles] MRI in acute disseminated encephalomyelitis following Semple antirabies vaccine. Neuroradiology. 1998 Jul;40(7):420-3. PMID: 9730339; UI: 98398107.
Prozesky OW. [See Related Articles] Neurological complications of rabies vaccines. S Afr Med J. 1978 May 20;53(20):780. No abstract available.PMID: 694620; UI: 79014557.
Osuch T, et al. [See Related Articles] [Complications following rabies vaccination]. Przegl Epidemiol. 1972;26(4):479-83. Polish. No abstract available.PMID: 4680439; UI: 75121120.
Rui DY. [See Related Articles] [Neurologic complications caused by rabies vaccine: analysis of 46 cases]. Chung Hua Shen Ching Ching Shen Ko Tsa Chih. 1982 Sep;15(3):175-6. Chinese. No abstract available.PMID: 7151581; UI: 83104524.

Rebucci GG, Cattania F. [Polyradiculoneuritis of the Guillain-Barre type following vaccination against rabies and smallpox. (Presentation of 2 cases)]Riv Neurobiol. 1965 Oct-Dec;11(4):669-82. Italian. No abstract available.PMID: 5888021 [PubMed - indexed for MEDLINE]

Saraiva PA, de Assis JL, Tiriba Ada C. [Neurological complications associated with anti-rabies vaccination in Sao Paulo: therapeutic, clinical and epidemiological aspects of 59 cases]Rev Paul Med. 1972 Aug;80(2):63-70. Portuguese. No abstract available.PMID: 4671574 [PubMed - indexed for MEDLINE]

Saint-Denis P, et al. [See Related Articles] [Rabies: prophylaxis and treatment. Apropos of a case of postvaccinal encephalomyelitis]. Union Med Can. 1968 Sep;97(9):1275-9. French. No abstract available.PMID: 4394863; UI: 71040541.
Sathe PV, et al. [See Related Articles]

da Silveira CM, Salisbury DM, de Quadros CA. Measles vaccination and Guillain-Barre syndrome.
Lancet. 1997 Jan 4;349(9044):14-6.PMID: 8988116 [PubMed - indexed for MEDLINE]

Schoop HD, Rohrbach P. [Progressive neurological complications after rabies immunization with Hempt vaccine]Dtsch Med Wochenschr. 1974 Sep 27;99(39):1923-6. German. No abstract available.PMID: 4420696 [PubMed - indexed for MEDLINE]

Subutay N, Isik N, Zileli T. [Neurologic complications due to a sample type of rabies vaccination]Mikrobiyol Bul. 1987 Apr;21(2):145-50. Turkish.PMID: 3447020 [PubMed - indexed for MEDLINE]

Shivanand PG, et al. Leucocyte migration inhibition test in post-antirabies vaccinal encephalitis (a preliminary communication). J Postgrad Med. 1981 Oct;27(4):222-5. PMID: 6121912; UI: 82170066.

Shaul JF, et al. Duck embryo rabies vaccine. Anaphylactic reaction following initial injection. J S C Med Assoc. 1969 Oct;65(10):359-61. No abstract available.PMID: 5272125; UI: 70285226.

Subutay N, et al. [See Related Articles] [Neurologic complications due to a sample type of rabies vaccination]. Mikrobiyol Bul. 1987 Apr;21(2):145-50. Turkish. PMID: 3447020; UI: 88189069. Neuroparalytic accidents due to sample type rabies vaccination are still an important problem in our country. We present seven patients with ascending polyneuritis, due to rabies vaccine, treated between 1982-1986, and discuss the importance of the problem.
Sinnecker H, et al. [See Related Articles] [Complicatons following rabies vaccination and their possibilities of treatment]. Z Arztl Fortbild (Jena). 1976 Mar 15;70(6):306-10. German. No abstract available. PMID: 9745; UI: 77017622.
Schlenska GK. [See Related Articles] Neurological complications following rabies duck embryo vaccination. J Neurol. 1976 Nov 26;214(1):71-4. No abstract available.PMID: 62829; UI: 77053082.
Stelmasiak Z, et al. [See Related Articles] [Case of acute disseminated encephalomyelitis in the course of anti-rabies vaccination]. Pol Tyg Lek. 1971 Aug 2;26(31):1198-9. Polish. No abstract available.

Tornatore CS, Richert JR. CNS demyelination associated with diploid cell rabies vaccine. Lancet. 1990 Jun 2;335(8701):1346-7. No abstract available. PMID: 1971408 [PubMed - indexed for MEDLINE]

Trocha H, et al. [See Related Articles] [Neurological complications of anti-rabies vaccination with the Semple vaccine]. Pol Tyg Lek. 1987 Aug 31;42(35):1077-9. Polish. No abstract available.PMID: 2893364; UI: 88124474.
Toro G, et al. Neuroparalytic accidents of antirabies vaccination with suckling mouse brain vaccine. Clinical and pathologic study of 21 cases. Arch Neurol. 1977 Nov;34(11):694-700. PMID: 911231; UI: 78019328.[See Related Articles]: Twenty-one cases of neuroparalytic accidents of rabies vaccination (with suckling mouse brain vaccine), 11 of them fatal, were observed, occurring predominantly in men; the mean age of the patients was 29 years. On the average, 13 doses of the vaccine were used. Only three patients received less than seven doses. The mean latent period was 14 days (range, 4 to 24 days). In 16 patients (76%), a Guillain-Barre syndrome occurred that was moderate in three, severe in seven, and fatal in six. Pathologically, this was shown to be a typical polyradiculoneuritis. Five patients had fatal involvement of the central nervous system. Three had an acute disseminated perivenous leukoencephalopathy, with concurrent rabies encephalitis in one case. One patient had a perivenous myeloradiculopathy and one a chronic encephalomyelopathy of six years' duration with demyelinating plaques in the periventricular white matter, cerebellum, and spinal cord. Since the reduction of postexposure rabies vaccination to seven doses, no new cases have been observed in Colombia.

Tornatore CS, Richert JR, "CNS demyelination associated with diploid cell rabies vaccine." Lancet 1990 Jun 2;335(8701):1346-1347.

Ubol S, et al. Antibody to peptides of human myelin basic protein in post-rabies vaccine encephalomyelitis sera. J Neuroimmunol. 1990 Feb;26(2):107-11. PMID: 1688875; UI: 90131050.[See Related Articles]

Development of neurologic complications after Semple rabies vaccine is closely linked to development of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassay in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89 and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic complication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 45-170. PMID: 1688875, UI: 90131050

Vasilos AF. [See Related Articles] [Clinical aspects and therapy of neuropathological complications after anti-rabies vaccination]. Vrach Delo. 1965 Jan;1:108-11. Russian. No abstract available.PMID: 4379112; UI: 66069237.

Wilcock BP, et al. [See Related Articles] Focal cutaneous vasculitis and alopecia at sites of rabies vaccination in dogs. J Am Vet Med Assoc. 1986 May 15;188(10):1174-7. PMID: 3721967; UI: 86250293.

Vaidya CH, et al. Polyneuritis--a complication of antirabic vaccination. J Postgrad Med. 1970 Jul;16(3):132-4. No abstract available.PMID: 5472424; UI: 71011461

Van der Meyden CH, et al. Neurological complications of rabies vaccines. S Afr Med J. 1978 Apr 1;53(13):478. No abstract available.PMID: 27870; UI: 78228867.

Wilbrandt D, et al. [Rabies vaccination and neuroparalytic postvaccinal complications. Case report]. Dtsch Gesundheitsw. 1972 Nov 16;27(46):2184-7. German. No abstract available.PMID: 4405458; UI: 73087932.
Warrell MJ, et al. Rapid diagnosis of rabies and post-vaccinal encephalitides. Clin Exp Immunol. 1988 Feb;71(2):229-34. PMID: 2894908; UI: 88165606.

Zintchenko (1965) has reported 12 patients in whom multiple sclerois first became evident after a course of anti-rabies vaccination--British Medical Journal 2:210-213, 1967.

ANIMAL
Rehulova E, et al. [Neural complications after preventive vaccination of beagles against rabies]. Vet Med (Praha). 1971 Sep;16(9):571-4. Czech. No abstract available.PMID: 4400548; UI: 72107112.

Rabies vaccine

This response submitted by on 12/24/98.
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I am a 48 yr old female and was bitten when I was about 8 yrs old...It is my understanding that the older form of rabies vaccine is the worst for causing neuro symptoms....I dont think I was ever the same afteer the vaccines (looking back everyone thought I was normal but I know now I was not . ...something was wrong with me but I had to break befor it was recognized...It started with obcessive compulsive behavior right after that(now I want you to know I am in a very emotionally balanced family...no problems..no stresses causing the symptoms) Then as I got older, I just didnt have as much energy as my peers...my legs gave out...I got fatigued so easily....was just so exausted...got weaker....just didnt feel like doing anything ....mentally I had ambition but that is as far as my ambition got....THen when I was 21, I had a host of problems related to the autonomic nervous system which no on e knew was the cause or understood......When I was 36, I literly felt like I was dying...body began to shut down and was sooooo weak..A fter going to 4 neurologist, I went to a major center and was diagnosed as having demylinating neurapathy with dysautonomia......not much they can do except treat the symptoms....as for me, I pray for a miracle and do the alternative treatment. It has been 10 yrs since my diagnosis and I am still here where as I thought Id be dead or at least in a wheel chair by now.....Let me know more about your situation...was so glad to have somone to talk to about this since it is never mentioned...Blessings to you this and all Christmas......Thanks

http://neuro-www.mgh.harvard.edu/forum/VaccineorDTPInjuriesF/Sure..begladto.html

Rabies vaccine

This article submitted by S.M. on 12/24/98.
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Has anyone ever had trouble with rabies vaccine? When I was 5yrs old (1976) I received the 23 rabie shots in my stomach for a severe facial dog bite. In 1993 I began having demyelination in my rt arm, also numb patches on all my limbs. Recent diagnosis is a immune mediated polyneurolpathy. She would like to call in CIDP but I no longer have any motor demyelination, it is all sensory related. Although I do have general progressive limb weakness in my upper extremities. ALso joint pain in my rt knee, hip, and rt thumb.

Was just wondering if anyone has any information regarding this. It would be very helpful for me. Thank you

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