Drug induced aseptic meningitis (DIAM) citations
[back] DIAM  [back] Infections from drugs/poisons

Antibiotics: Amoxicillin, Trimethoprim, co-trimoxazole (trimethoprim-sulfamethoxazole) Metronidazole. 
Nonsteroidal anti-inflammatory: rofecoxib, Ibuprofen

Antibiotic &  vaccine associated paralytic Poliomyelitis (VAPP)
[Media UK, 1996] Meningitis clusters linked to antibiotics (erythromycin)

Andrade A, Hilmas E, Walter C.  A rare occurrence of trimethoprim/sulfamethoxazole (TMP/SMX)-induced aseptic meningitis in an older woman.J Am Geriatr Soc. 2000 Nov;48(11):1537-8. No abstract available.PMID: 11083344 [PubMed - indexed for MEDLINE]
Antonen J, Hulkkonen J, Pasternack A, Hurme M. Interleukin 6 may be an important mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis.Arch Intern Med. 2000 Jul 10;160(13):2066-7. No abstract available.PMID: 10888991 [PubMed - indexed for MEDLINE]
Alloway JA, Mitchell SR.  Sulfasalazine neurotoxicity: a report of aseptic meningitis and a review of the literature.J Rheumatol. 1993 Feb;20(2):409-11. Review. No abstract available.PMID: 8097252 [PubMed - indexed for MEDLINE]
Auxier GG. Aseptic meningitis associated with administration of trimethoprim and sulfamethoxazole.Am J Dis Child. 1990 Feb;144(2):144-5. No abstract available.PMID: 2301318 [PubMed - indexed for MEDLINE]
Asmar BI, Maqbool S, Dajani AS.Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children.Am J Dis Child. 1981 Dec;135(12):1100-3.PMID: 7315805 [PubMed - indexed for MEDLINE]

Barak S, Shaked Y, Bar ZG, Samra Y.Drug-induced post-surgical haemorrhage resulting from trimethoprim-sulphamethoxazole. A case report.Int J Oral Maxillofac Surg. 1989 Aug;18(4):206-7.PMID: 2507668 [PubMed - indexed for MEDLINE]
Berliner S, Weinberger A, Shoenfeld Y, Sandbank U, Hazaz B, Joshua H, Rosen M, Pinkhas J.Ibuprofen may induce meningitis in (NZB X NZW)F1 mice.Arthritis Rheum. 1985 Jan;28(1):104-7. No abstract available.PMID: 3966933 [PubMed - indexed for MEDLINE]
Barbot F, Danan-Causanski S, Chaouat D, Thuong M.[Aseptic meningitis after ranitidine treatment for systemic lupus erythematosus]Presse Med. 1999 Nov 13;28(35):1938. French. No abstract available.PMID: 10598151 [PubMed - indexed for MEDLINE]
Ballas ZK, Donta ST.  Sulindac-induced aseptic meningitis.Arch Intern Med. 1982 Jan;142(1):165-6.PMID: 7053720 [PubMed - indexed for MEDLINE]
Biosca M, de la Figuera M, Garcia-Bragado F, Sampol G. Aseptic meningitis due to trimethoprim-sulfamethoxazole.J Neurol Neurosurg Psychiatry. 1986 Mar;49(3):332-3. No abstract available.PMID: 3958749 [PubMed - indexed for MEDLINE]
Bouland DL, Specht NL, Hegstad DR.  Ibuprofen and aseptic meningitis.Ann Intern Med. 1986 May;104(5):731. No abstract available.PMID: 3963677 [PubMed - indexed for MEDLINE]
Bonnel RA, Villalba ML, Karwoski CB, Beitz J.Aseptic meningitis associated with rofecoxib.Arch Intern Med. 2002 Mar 25;162(6):713-5.PMID: 11911727 [PubMed - in process]

Carrillo F, Cubero A, Hernandez Gallego J, Jimenez Santana P. [Recurrence of meningoencephalitis induced by cotrimoxazole]Rev Neurol. 1995 Jan-Feb;23(119):142-4. Spanish.PMID: 8548610 [PubMed - indexed for MEDLINE]
Capra C, Monza GM, Meazza G, Ramella G.   Trimethoprim-sulfamethoxazole-induced aseptic meningitis: case report and literature review.Intensive Care Med. 2000 Feb;26(2):212-4. Review.PMID: 10784311 [PubMed - indexed for MEDLINE]
Czerwenka WM.Amoxicillin can induce aseptic meningitis.Arch Intern Med. 1999 Dec 13-27;159(22):2746. No abstract available.PMID: 10597768 [PubMed - indexed for MEDLINE]
Chaudhry HJ, Cunha BA. Drug-induced aseptic meningitis. Diagnosis leads to quick resolution. Postgrad Med. 1991 Nov 15;90(7):65-70. Review. PMID: 1946120 [PubMed - indexed for MEDLINE]
Corson AP, Chretien JH.  Metronidazole-associated aseptic meningitis.Clin Infect Dis. 1994 Nov;19(5):974. No abstract available.PMID: 7893894 [PubMed - indexed for MEDLINE]
Czerwenka W, Gruenwald C, Conen D.  Aseptic meningitis after treatment with amoxicillin.BMJ. 1999 Jun 5;318(7197):1521. No abstract available.PMID: 10356006 [PubMed - indexed for MEDLINE]
Capra C, Monza GM, Meazza G, Ramella G. Trimethoprim-sulfamethoxazole-induced aseptic meningitis: case report and literature review.Intensive Care Med. 2000 Feb;26(2):212-4. Review.PMID: 10784311 [PubMed - indexed for MEDLINE]
10597768 [PubMed - indexed for MEDLINE]
Carlson J, Wiholm BE.Trimethoprim associated aseptic meningitis.Scand J Infect Dis. 1987;19(6):687-91.PMID: 3502034 [PubMed - indexed for MEDLINE]

Durand JM, Suchet L, Morange S, Michel B. Ranitidine and aseptic meningitis.BMJ. 1996 Apr 6;312(7035):886. No abstract available.PMID: 8611881 [PubMed - indexed for MEDLINE]

Derbes SJ.Trimethoprim-induced aseptic meningitis.JAMA. 1984 Nov 23-30;252(20):2865-6. No abstract available.PMID: 6333524 [PubMed - indexed for MEDLINE]
Durback MA, Freeman J, Schumacher VR Jr.Recurrent ibuprofen-induced aseptic meningitis: third episode after only 200 mg of generic ibuprofen.Arthritis Rheum. 1988 Jun;31(6):813-5. No abstract available.PMID: 3382456 [PubMed - indexed for MEDLINE]
Dang CT, Riley DK.Aseptic meningitis secondary to carbamazepine therapy.Clin Infect Dis. 1996 Apr;22(4):729-30. Review. No abstract available.PMID: 8729227 [PubMed - indexed for MEDLINE]
Davis BJ, Thompson J, Peimann A, Bendixen BH.Drug-induced aseptic meningitis caused by two medications.Neurology. 1994 May;44(5):984-5. No abstract available.PMID: 8190318 [PubMed - indexed for MEDLINE]

Ellison DH. Hyperkalemia and trimethoprim-sulfamethoxazole.Am J Kidney Dis. 1997 Jun;29(6):959-62; discussion 962-5. No abstract available.PMID: 9186085 [PubMed - indexed for MEDLINE]
Ewert BH.Ibuprofen-associated meningitis in a woman with only serologic evidence of a rheumatologic disorder.Am J Med Sci. 1989 May;297(5):326-7.PMID: 2785759 [PubMed - indexed for MEDLINE]
Escalante A, Stimmler MM.Trimethoprim-sulfamethoxasole induced meningitis in systemic lupus erythematosus.J Rheumatol. 1992 May;19(5):800-2.PMID: 1613713 [PubMed - indexed for MEDLINE]
Most reports of drug induced meningitis in systemic lupus erythematosus (SLE) have implicated ibuprofen. We describe a 46-year-old woman with SLE who developed aseptic meningitis abruptly after ingesting trimethoprim-sulfamethoxasole (TMP-SMX). This patient had received TMP-SMX twice before; each was associated with increasingly severe reactions, whose relationship with the use of TMP-SMX became apparent only in retrospect. A history of medication use should be sought in all patients with meningitis who have an underlying autoimmune disorder.

Figg WD.Aseptic meningitis associated with muromonab-CD3.DICP. 1991 Dec;25(12):1395. No abstract available.PMID: 1815441 [PubMed - indexed for MEDLINE]

Grimm AM, Wolf JE.Aseptic meningitis associated with nonprescription ibuprofen use.DICP. 1989 Sep;23(9):712. No abstract available.PMID: 2800589 [PubMed - indexed for MEDLINE]
Greenberg GN.Recurrent sulindac-induced aseptic meningitis in a patient tolerant to other nonsteroidal anti-inflammatory drugs.
South Med J. 1988 Nov;81(11):1463-4.PMID: 3187641 [PubMed - indexed for MEDLINE]
Gordon MF, Allon M, Coyle PK.Drug-induced meningitis.Neurology. 1990 Jan;40(1):163-4.PMID: 2296366 [PubMed - indexed for MEDLINE]
Meningitis is usually produced by an infectious agent, but there are multiple noninfectious causes. Medications may produce both acute and recurrent meningitis. We present a patient with 3 episodes of aseptic meningitis due to trimethoprim-sulfamethoxazole, and then review the topic of drug-induced meningitis.
Giansiracusa DF, Blumberg S, Kantrowitz FG.Aseptic meningitis associated with ibuprofen.Arch Intern Med. 1980 Nov;140(11):1553. No abstract available.PMID: 7436656 [PubMed - indexed for MEDLINE]
Gilroy N, Gottlieb T, Spring P, Peiris O. Trimethoprim-induced aseptic meningitis and uveitis.Lancet. 1997 Jul 12;350(9071):112. No abstract available.PMID: 9228966 [PubMed - indexed for MEDLINE

Harrison MS, Simonte SJ, Kauffman CA.Trimethoprim-induced aseptic meningitis in a patient with AIDS: case report and review.Clin Infect Dis. 1994 Sep;19(3):431-4. Review.PMID: 7811861 [PubMed - indexed for MEDLINE]
Hanson L.Ibuprofen-induced aseptic meningitis.J Tenn Med Assoc. 1994 Feb;87(2):58. No abstract available.PMID: 8176914 [PubMed - indexed for MEDLINE]
Horn AC, Jarrett SW.  Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. Ann Pharmacother. 1997 Sep;31(9):1009-11. PMID: 9296242 [PubMed - indexed for MEDLINE]
OBJECTIVE: To report a case of aseptic meningitis related to ibuprofen ingestion. CASE SUMMARY: We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen. A diagnosis of ibuprofen-induced aseptic meningitis was made based on the patient's physical and laboratory findings, the quick onset and resolution of symptoms, and his medical history. DISCUSSION: Ibuprofen-induced aseptic meningitis has been most frequently reported in patients with systemic lupus erythematosus. However, there have been reports of this reaction in patients with other underlying disease states. Various nonsteroidal antiinflammatory drugs have been reported to cause this reaction, but ibuprofen is the most common offending agent. A drug-related cause should be considered in any patient who presents with typical meningitis symptoms, such as fever, headache, and stiff neck, that occur within hours of ingesting a drug. CONCLUSIONS: Although persons with systemic lupus erythematosus appear to have an increased risk for this type of reaction, the development of signs and symptoms in other patients warrants the consideration of nonsteroidal antiinflammatory drugs as the cause of aseptic meningitis.
Herlihy TE.  Phenazopyridine and aseptic meningitis. Ann Intern Med. 1987 Jan;106(1):172-3. No abstract available. PMID: 3789573 [PubMed - indexed for MEDLINE]
Hoppmann RA, Peden JG, Ober SK.  Central nervous system side effects of nonsteroidal anti-inflammatory drugs. Aseptic meningitis, psychosis, and cognitive dysfunction.Arch Intern Med. 1991 Jul;151(7):1309-13. Review.PMID: 2064481 [PubMed - indexed for MEDLINE]

Jick H, Derby LE. Is co-trimoxazole safe?Lancet. 1995 Apr 29;345(8957):1118-9. No abstract available.PMID: 7715367 [PubMed - indexed for MEDLINE]
Jurado R, Carpenter SL, Rimland D. Case reports: trimethoprim-sulfamethoxazole-induced meningitis in patients with HIV infection.Am J Med Sci. 1996 Jul;312(1):27-9.PMID: 8686726 [PubMed - indexed for MEDLINE]
Joffe AM, Farley JD, Linden D, Goldsand G. Trimethoprim-sulfamethoxazole-associated aseptic meningitis: case reports and review of the literature.Am J Med. 1989 Sep;87(3):332-8. Review. No abstract available.PMID: 2672812 [PubMed - indexed for MEDLINE]
Jacobsson G, Elowson S.  [Amoxicillin caused aseptic meningoencephalitis]Lakartidningen. 1999 Jan 20;96(3):201-2. Swedish. No abstract available.PMID: 10068320 [PubMed - indexed for MEDLINE]
Jolles S, Sewell WA, Leighton C.  Drug-induced aseptic meningitis: diagnosis and management. Drug Saf. 2000 Mar;22(3):215-26. Review.PMID: 10738845 [PubMed - indexed for MEDLINE]
Drug-induced aseptic meningitis (DIAM) has been reported as an uncommon adverse reaction with numerous agents. It is a diagnosis of exclusion, and clinical signs and CSF findings vary greatly. The body of evidence regarding DIAM is largely in the form of anecdotal case reports and must be interpreted carefully bearing this in mind. The major categories of causative agents are nonsteroidal anti-inflammatory drugs, antimicrobials, intravenous immunoglobulin, intrathecal agents, vaccines and a number of other less frequently reported agents. There appears to be an association between DIAM and connective tissue disease, particularly systemic lupus erythematosus, and ibuprofen. There are 2 major proposed mechanisms for DIAM. The first involves direct irritation of the meninges by intrathecal administration of the drug, and the second involves immunological hypersensitivity to the drug, most likely type III and type IV hypersensitivity. Recognition and diagnosis of DIAM is important, as it is treatable by withdrawal of the drug and recurrence is prevented. The outcome of DIAM is generally good, usually without long term sequelae. This article describes the case reports of DIAM in the current literature and discusses the diagnosis and management of this rare complication.

Joy ME, Michals ML, Canafax DM.Aseptic meningitis associated with muromonab-CD3 therapy.Clin Pharm. 1988 Oct;7(10):721. No abstract available.PMID: 3233895 [PubMed - indexed for MEDLINE]

Kaplan BH, Nevitt MP, Pach JM, Herman DC.Aseptic meningitis and iridocyclitis related to ibuprofen.Am J Ophthalmol. 1994 Jan 15;117(1):119-20. No abstract available.PMID: 8291583 [PubMed - indexed for MEDLINE]
Kremer I, Ritz R, Brunner F. Aseptic meningitis as an adverse effect of co-trimoxazole.N Engl J Med. 1983 Jun 16;308(24):1481. No abstract available.PMID: 6602292 [PubMed - indexed for MEDLINE]
Kindmark CO, Carlsson U, Hedback B, Tove H.  [Aseptic meningitis after treatment with ibuprofen]Lakartidningen. 1987 Sep 2;84(36):2782-3. Swedish. No abstract available.PMID: 3669815 [PubMed - indexed for MEDLINE]
Karlsson M. [Symptoms of meningitis after trimethoprim treatment]Lakartidningen. 1986 Aug 6;83(32-33):2666-7. Swedish. No abstract available.PMID: 3747651 [PubMed - indexed for MEDLINE]
Katona BG, Wigley FM, Walters JK, Caspi M.Aseptic meningitis from over-the-counter ibuprofen.Lancet. 1988 Jan 2-9;1(8575-6):59. No abstract available.PMID: 2891924 [PubMed - indexed for MEDLINE]

Lafferty TE, DeHoratius RJ, Smith JB.Aseptic meningitis as a side effect of intravenous immune gammaglobulin.J Rheumatol. 1997 Dec;24(12):2491-2. No abstract available.PMID: 9415672 [PubMed - indexed for MEDLINE]
Levitz RE, Dudley MN, Quintiliani R, Mullany LD, Nightingale CH.Cerebrospinal fluid penetration of trimethoprim-sulphamethoxazole in two patients with gram-negative bacillary meningitis.J Antimicrob Chemother. 1984 Apr;13(4):400-1. No abstract available.PMID: 6609920 [PubMed - indexed for MEDLINE]
Lawson JM, Grady MJ.Ibuprofen-induced aseptic meningitis in a previously healthy patient.West J Med. 1985 Sep;143(3):386-7. No abstract available.PMID: 4049858 [PubMed - indexed for MEDLINE]
Lewis RJ. Fatal vasculitis following treatment with co-trimoxozole.Br J Rheumatol. 1995 Jan;34(1):84-5. No abstract available.
PMID: 7881847 [PubMed - indexed for MEDLINE]

Marinac JS.  Drug- and chemical-induced aseptic meningitis: a review of the literature. Ann Pharmacother. 1992 Jun;26(6):813-22. Review. PMID: 1611165 [PubMed - indexed for MEDLINE]
OBJECTIVE: The primary objective of this article is to provide readers with case reports of drug- or chemical-induced aseptic meningitis (DCAM) described in the medical literature. Background information regarding the classification of DCAM, incidence, proposed mechanisms, associated risk factors, clinical management, and sequelae is presented. DATA SOURCES: A MEDLINE search was used to identify pertinent background literature and case reports of DCAM. DATA EXTRACTION: All case reports of DCAM involve anecdotal information. A critical analysis of a causal relationship to the implicated drug or chemical and the appearance of meningeal involvement is presented. Animal data are included when pertinent. DATA SYNTHESIS: DCAM is a rare adverse event associated with numerous agents. Patients present with a variety of clinical signs and symptoms and laboratory findings of cerebral spinal fluid, when obtained, vary greatly. Most patients fully recover without sequelae. CONCLUSIONS: Numerous drugs and chemicals have been implicated in the medical literature as producing DCAM. Two proposed mechanisms of DCAM have been theorized: a delayed hypersensitivity-type reaction and direct meningeal irritation. The nonsteroidal antiinflammatory drugs, certain antibiotics, radiographic agents, and muromonab-CD3 have been most frequently implicated. There appears to be an association between the occurrence of the hypersensitivity-type reactions and underlying collagen vascular or rheumatologic disease.
de la Monte SM, Hutchins GM, Gupta PK.Aseptic meningitis, trimethoprim, and Sjogren's syndrome.JAMA. 1985 Apr 19;253(15):2192. No abstract available.PMID: 3871870 [PubMed - indexed for MEDLINE]
Muller MP, Richardson DC, Walmsley SL. Trimethoprim-sulfamethoxazole induced aseptic meningitis in a renal transplant patient.Clin Nephrol. 2001 Jan;55(1):80-4. Review.PMID: 11200873 [PubMed - indexed for MEDLINE]
Mifsud AJ. Drug-related recurrent meningitis.J Infect. 1988 Sep;17(2):151-3.PMID: 3183406 [PubMed - indexed for MEDLINE]
Moris G, Garcia-Monco JC.  The challenge of drug-induced aseptic meningitis. Arch Intern Med. 1999 Jun 14;159(11):1185-94. Review. PMID: 10371226 [PubMed - indexed for MEDLINE]
Several drugs can induce the development of aseptic meningitis. Drug-induced aseptic meningitis (DIAM) can mimic an infectious process as well as meningitides that are secondary to systemic disorders for which these drugs are used. Thus, DIAM constitutes a diagnostic and patient management challenge. Cases of DIAM were reviewed through a MEDLINE literature search (up to June 1998) to identify possible clinical and laboratory characteristics that would be helpful in distinguishing DIAM from other forms of meningitis or in identifying a specific drug as the culprit of DIAM. Our review showed that nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, intravenous immunoglobulins, and OKT3 antibodies (monoclonal antibodies against the T3 receptor) are the most frequent cause of DIAM. Resolution occurs several days after drug discontinuation and the clinical and cerebrospinal fluid profile (neutrophilic pleocytosis) do not allow DIAM to be distinguished from infectious meningitis. Nor are there any specific characteristics associated with a specific drug. Systemic lupus erythematosus seems to predispose to NSAID-related meningitis. We conclude that a thorough history on prior drug intake must be conducted in every case of meningitis, with special focus on those aforementioned drugs. If there is a suspicion of DIAM, a third-generation cephalosporin seems a reasonable treatment option until cerebrospinal fluid cultures are available.
Meng MV, St Lezin M.Trimethoprim-sulfamethoxazole induced recurrent aseptic meningitis.J Urol. 2000 Nov;164(5):1664-5. No abstract available.PMID: 11025739 [PubMed - indexed for MEDLINE]
Maignen F, Castot A, Falcy M, Efthymiou ML.  [Drug-induced aseptic meningitis]Therapie. 1992 Sep-Oct;47(5):399-402. Review. French.PMID: 1299979 [PubMed - indexed for MEDLINE]
Aseptic meningitis is a very rare drug reaction involving non-steroidal antiinflammatory agents (ibuprofen and sulindac), antibiotics (cotrimoxazole, trimethoprim, ciprofloxacin) and miscellaneous drugs such as carbamazepine, human immune globulin and muromonab CD3. Meningeal symptoms occur a few hours after drug intake and resolve without sequelae within one or two days after drug withdrawal, mainly in young females with systemic lupus erythematosus or mixed connective tissue disease. Biological findings and radiological investigations are not suggestive of an infectious etiology or rheumatological/neurological disturbances. Diagnosis is simple when recurrent episodes coincide with drug ingestion.
Marinac JS, Stanford JF. A severe hypersensitive reaction to trimethoprim-sulfamethoxazole in a patient infected with human immunodeficiency virus.Clin Infect Dis. 1993 Jan;16(1):178-9. No abstract available.PMID: 8448304 [PubMed - indexed for MEDLINE]
Nair J, Stacy M.Aseptic meningitis associated with salicylate overdose.Psychosomatics. 1993 Jul-Aug;34(4):372. No abstract available.PMID: 8351314 [PubMed - indexed for MEDLINE]

Oddou S, Molinier S, Coso D, Boulet JM, Gastaut JA, Bouabdallah R.   [Aseptic meningitis following treatment with immunoglobulins: physiopathological and prognostic value of screening]Presse Med. 1995 May 27;24(19):916. French. No abstract available.PMID: 7638138 [PubMed - indexed for MEDLINE]

Parkes AJ. Trimethoprim-sulfamethoxazole in the veteran population: is it still being prescribed despite recognised complications?Med J Aust. 1995 Apr 17;162(8):445. No abstract available.PMID: 7746191 [PubMed - indexed for MEDLINE]
Poles L, Theodor E.[Trimethoprim-sulphamethoxazole-induced meningitis]Harefuah. 1996 Jun 16;130(12):817-9, 879. Hebrew.PMID: 8885504 [PubMed - indexed for MEDLINE]
Pisani E, Fattorello C, Leotta MR, Marcello O, Zuliani C.  Recurrence of ibuprofen-induced aseptic meningitis in an otherwise healthy patient.Ital J Neurol Sci. 1999 Feb;20(1):59-62.PMID: 10933487 [PubMed - indexed for MEDLINE]
Preminger-Shapiro R, Nussinovitch M, Soen G, Varsano I.  Aseptic meningitis: a frequent side-effect of intravenous immunoglobulin?Eur J Pediatr. 1995 Oct;154(10):866-7. No abstract available.PMID: 8529693 [PubMed - indexed for MEDLINE]
Roel JE, Gadano AC, Falcon JL.  [Ketoprofen and aseptic meningitis] Medicina (B Aires). 1991;51(2):186. Spanish. No abstract available. PMID: 1820511 [PubMed - indexed for MEDLINE]
Peck MG, Joyner PU.Ibuprofen-associated aseptic meningitis.Clin Pharm. 1982 Nov-Dec;1(6):561-5. No abstract available.PMID: 7185548 [PubMed - indexed for MEDLINE]
Pisani E, Fattorello C, Leotta MR, Marcello O, Zuliani C.Recurrence of ibuprofen-induced aseptic meningitis in an otherwise healthy patient.Ital J Neurol Sci. 1999 Feb;20(1):59-62.PMID: 10933487 [PubMed - indexed for MEDLINE]
Preminger-Shapiro R, Nussinovitch M, Soen G, Varsano I.Aseptic meningitis: a frequent side-effect of intravenous immunoglobulin?Eur J Pediatr. 1995 Oct;154(10):866-7. No abstract available.PMID: 8529693 [PubMed - indexed for MEDLINE]
Pashankar D, McArdle M, Robinson A. Co-trimoxazole induced aseptic meningitis.Arch Dis Child. 1995 Sep;73(3):257-8.PMID: 7492171 [PubMed - indexed for MEDLINE]
Patey O, Lacheheb A, Dellion S, Zanditenas D, Jungfer-Bouvier F, Lafaix C. A rare case of cotrimoxazole-induced eosinophilic aseptic meningitis in an HIV-infected patient.Scand J Infect Dis. 1998;30(5):530-1.PMID: 10066062 [PubMed - indexed for MEDLINE]

Quinn JP, Weinstein RA, Caplan LR.Eosinophilic meningitis and ibuprofen therapy.Neurology. 1984 Jan;34(1):108-9.PMID: 6537831 [PubMed - indexed for MEDLINE]

Ristikankare M, Tarssanen L.[Trimethoprim-sulfadiazine-induced cholestasis]Duodecim. 1993;109(2):139-42. Finnish. No abstract available.PMID: 8013318 [PubMed - indexed for MEDLINE]
Rottach K, Scheglmann K, Pfadenhauer K.  Mollaret's meningitis: a new aetiologic feature.Eur Neurol. 1996;36(3):172-3. No abstract available.PMID: 8738949 [PubMed - indexed for MEDLINE]
Ruppert GB, Barth WF.  Tolmetin-induced aseptic meningitis.JAMA. 1981 Jan 2;245(1):67-8.PMID: 7431632 [PubMed - indexed for MEDLINE]
Rubin SI, Toolan L, Halperin ML. Trimethoprim-induced exacerbation of hyperkalemia in a dog with hypoadrenocorticism.J Vet Intern Med. 1998 May-Jun;12(3):186-8. No abstract available.PMID: 9595382 [PubMed - indexed for MEDLINE]
Ruiz-Irastorza G, Montejo M, Ituarte J, Aguirre C.[Prolonged cholestasis following single dose of cotrimoxazole++]Rev Clin Esp. 1996 Dec;196(12):879-80. Spanish. No abstract available.PMID: 9132870 [PubMed - indexed for MEDLINE]
River Y, Averbuch-Heller L, Weinberger M, Meiner Z, Mevorach D, Schlesinger I, Argov Z.Antibiotic induced meningitis.J Neurol Neurosurg Psychiatry. 1994 Jun;57(6):705-8. Review.PMID: 8006651 [PubMed - indexed for MEDLINE]
Rudy BJ, Rutstein R. Aseptic meningitis from trimethoprim-sulfamethoxazole in an HIV-infected adolescent.Pediatr Emerg Care. 1997 Jun;13(3):216-7.PMID: 9220510 [PubMed - indexed for MEDLINE]

Streiffer RH, Hudson JG. Aseptic meningitis and trimethoprim-sulfamethoxazole.J Fam Pract. 1986 Oct;23(4):314. No abstract available.PMID: 3489810 [PubMed - indexed for MEDLINE]
Sirvent N, Monpoux F, Benet L, Mariani R.  [Aseptic meningitis during treatment with immunoglobulins] Arch Pediatr. 1996 Aug;3(8):830-1. French. No abstract available. PMID: 8998543 [PubMed - indexed for MEDLINE]
Seaton RA, France AJ.  Recurrent aseptic meningitis following non- steroidal anti-inflammatory drugs--a reminder.Postgrad Med J. 1999 Dec;75(890):771-2.PMID: 10567617 [PubMed - indexed for MEDLINE]
Scribner CL, Kapit RM, Phillips ET, Rickles NM.  Aseptic meningitis and intravenous immunoglobulin therapy.Ann Intern Med. 1994 Aug 15;121(4):305-6. No abstract available.PMID: 8037414 [PubMed - indexed for MEDLINE]
Saha H, Lumio J, Pasternack A. [Acute aseptic meningitis induced by trimethoprim]Duodecim. 1988;104(4):257-61. Finnish. No abstract available.PMID: 3168833 [PubMed - indexed for MEDLINE]
Spigset O, Messner T.[Suppression of bone marrow after drug interaction]Lakartidningen. 1993 Jun 2;90(22):2138-40. Swedish. No abstract available.PMID: 8502067 [PubMed - indexed for MEDLINE]

Sutton JD, Prioleau MH, Wordell CJ, Francos GC.Aseptic meningitis associated with muromonab CD3 administration.DICP. 1989 Mar;23(3):257-8. No abstract available.PMID: 2497590 [PubMed - indexed for MEDLINE]

Tunkel AR, Starr K.Trimethoprim-sulfamethoxazole-associated aseptic meningitis.Am J Med. 1990 Jun;88(6):696-7. No abstract available.PMID: 2346166 [PubMed - indexed for MEDLINE]
Tonolli I, Velut JG, Lafay V, Thomachot L, Gambini D, Frances Y. [Cotrimoxazole-induced aseptic meningitis: two cases]Presse Med. 1998 Apr 18;27(15):716-7. French. No abstract available.PMID: 9767911 [PubMed - indexed for MEDLINE]
Thilmann AF, Mobius E, Thilmann RR, Topper R. [Recurrent aseptic meningitis (Mollaret meningitis)--spontaneous and drug-induced origin]Fortschr Neurol Psychiatr. 1991 Dec;59(12):493-7. German.PMID: 1774010 [PubMed - indexed for MEDLINE]
Watanakunakorn C. Hyperkalemia and trimethoprim-sulfamethoxazole.Ann Intern Med. 1996 Nov 1;125(9):778; discussion 779-80. No abstract available.PMID: 8929019 [PubMed - indexed for MEDLINE]
Wittmann A, Wooten GF.  Amoxicillin-induced aseptic meningitis.Neurology. 2001 Nov 13;57(9):1734. No abstract available.PMID: 11706130 [PubMed - indexed for MEDLINE]
Weksler BB, Lehany AM.  Naproxen-induced recurrent aseptic meningitis.DICP. 1991 Nov;25(11):1183-4.PMID: 1763533 [PubMed - indexed for MEDLINE]
Wong JG, Hathaway SC, Paat JJ, Paterson RW, Steele GH Jr. Drug-induced meningitis. A case involving trimethoprim-sulfamethoxazole.Postgrad Med. 1994 Nov 1;96(6):117-8, 121,124.PMID: 7971606 [PubMed - indexed for MEDLINE]
Drug-induced meningitis should be considered in differential diagnosis of meningeal irritation in patients receiving therapy with anti-infective, nonsteroidal anti-inflammatory, immunosuppressive, or other selected agents. This report describes a case of aseptic meningitis associated with use of trimethoprim-sulfamethoxazole in a patient without apparent underlying autoimmune disease. The patient recovered promptly after the offending agent was withdrawn. No specific treatment other than symptomatic and supportive care need be given. In all instances, however, infection must be excluded.

de Weerdt CJ, van de Poll MA.[Aseptic meningitis after use of Amipaque]Ned Tijdschr Geneeskd. 1980 Oct 18;124(42):1783-4. Dutch. No abstract available.PMID: 7432567 [PubMed - indexed for MEDLINE]
van der Zwan A, van Dam JG.[Ibuprofen meningitis]Ned Tijdschr Geneeskd. 1992 Aug 15;136(33):1613-4.Dutch.PMID: 1407096 [PubMed - indexed for MEDLINE]