Beneficial effect of childhood diseases   Chickenpox

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Cancer Med. 2016 Jun;5(6):1352-8. doi: 10.1002/cam4.682. Epub 2016 Mar 13.

History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).

Amirian ES1Scheurer ME1Zhou R1Wrensch MR2Armstrong GN1Lachance D3Olson SH4Lau CC1Claus EB5,6Barnholtz-Sloan JS7Il'yasova D8,9Schildkraut J9Ali-Osman F10Sadetzki S11,12Jenkins RB13Bernstein JL4Merrell RT14Davis FG15Lai R16Shete S17Amos CI18Melin BS19Bondy ML1.

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Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case-Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two-stage random-effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusting for age and sex (95% confidence intervals (CI): 0.65-0.96). Furthermore, the protective effect of chickenpox was stronger for high-grade gliomas. Our study provides additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental. Future studies, including meta-analyses of the literature and investigations of the potential biological mechanism, are warranted.

2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.


Brain tumor; chickenpox; glioma; shingles