Vaccines UK (BNF 42 2002) http://www.bnf.org/Index.htm
BCG Vaccines:
Bacillus Calmette-Guérin Vaccine BCG
Vaccine, Dried Tub/Vac/BCG. A freeze-dried preparation of live bacteria of a strain
derived from the bacillus of Calmette and Guérin.
Bacillus Calmette-Guérin Vaccine, Percutaneous Tub/Vac/BCG(Perc)
A preparation of live bacteria of a strain derived from the
bacillus of Calmette and Guérin (important: this preparation must not
be confused with the intradermal preparation)
Cholera vaccine
Cholera vaccine contains heat-killed Inaba and Ogawa sub-types of Vibrio cholerae, Serovar O1. Cholera vaccine provides little protection and cannot control the spread of the disease; it is no longer available in the UK.
Diphtheria vaccines
Diphtheria vaccines for children
With tetanus and pertussis (triple vaccine)
Adsorbed Diphtheria, Tetanus, and Pertussis Vaccine DTPer/Vac/Ads
Injection, suspension of diphtheria formol toxoid, tetanus formol toxoid, and pertussis vaccine adsorbed on a mineral carrier Dose: primary immunisation of children, by intramuscular or deep subcutaneous injection, 0.5 mL at 2 months followed by second dose after 4 weeks and third dose after another 4 weeks (see schedule, section 14.1)Available from Health Authorities or (in England only) direct from Farillon as Aventis Pasteur MSD Ltd brand (excipients include thiomersal) ® (Glaxo SmithKline) Injection, suspension of diphtheria toxoid, tetanus toxoid, and acellular pertussis vaccine components adsorbed on a mineral carrier, net price 0.5-mL prefilled syringe = £11.00With tetanus
Adsorbed Diphtheria and Tetanus Vaccine DT/Vac/Ads(Child)
Injection, suspension of diphtheria formol toxoid and tetanus formol toxoid adsorbed on a mineral carrier Dose: primary immunisation of children omitting pertussis component, by intramuscular or deep subcutaneous injection, 0.5 mL at 2 months followed by second dose after 4 weeks and third dose after another 4 weeks (see schedule, section 14.1); booster at school entry, 0.5 mL (see schedule, section 14.1) Available from Health Authorities or (in England only) direct from Farillon as Evans Vaccines brand (excipients include thiomersal) or Aventis Pasteur MSD Ltd brand (excipients include thiomersal)Diphtheria vaccines for adolescents and adults
With tetanus
DIFTAVAX Adsorbed Diphtheria Vaccine for Adults and Adolescents Dip/Vac/Ads(Adult) Injection, diphtheria formol toxoid adsorbed on a mineral carriernet price 0.5-mL prefilled syringe = £2.67 Dose: primary immunisation in patients over 10 years, by intramuscular or deep subcutaneous injection, 3 doses each of 0.5 mL separated by intervals of 4 weeks; booster, 0.5 mL after 10 years Available from Health Authorities or (in England only) direct from Farillon as Aventis Pasteur MSD Ltd brand (Diftavax®; excipients include thiomersal)
Single antigen
Adsorbed Diphtheria Vaccine for Adults and Adolescents Dip/Vac/Ads(Adult)
Injection, diphtheria formol toxoid adsorbed on a mineral carrier Dose: primary immunisation in patients over 10 years, by intramuscular or deep subcutaneous injection, 3 doses each of 0.5 mL separated by intervals of 1 month; booster, 0.5 mL Booster in children under 10 years (when tetanus booster already given) [unlicensed use], see notes above Note. Unimmunised adults and children over 10 years who are contacts of a diphtheria case or carrier are given the primary immunisation course; immunised adults and children over 10 years are given the booster dose. Available from Health Authorities or (in England only) direct from FarillonDiphtheria antitoxin
Diphtheria antitoxin is used for passive immunisation; it is prepared in horses therefore reactions are common after administration. It is now only used in suspected cases of diphtheria (without waiting for bacteriological confirmation); tests for hypersensitivity should be first carried out. It is no longer used for prophylaxis because of the risk of hypersensitivity; unimmunised contacts should be promptly investigated and given erythromycin prophylaxis (section 5.1, table 2) and vaccine (see notes above).
Diphtheria Antitoxin
Dip/Ser. Dose: prophylactic by intramuscular injection, 500–2000 units (but not used, see notes above); therapeutic 10 000–30 000 units increased to 40 000–100 000 units in severe cases; doses of up to 30 000 units should be given intramuscularly but for those over 40 000 units a portion is given intramuscularly followed by the bulk of the dose intravenously after an interval of ½–2 hours Note. Children require the same dose as adults, depending on the severity of the case. Available from Communicable Disease Surveillance Centre (Tel (020) 8200 6868) or in Northern Ireland from Public Health Laboratory, Belfast City Hospital (Tel (028) 9032 9241).Haemophilus influenzae type B vaccine
Single component
Each single component product may be used to complete a course started with any other single component product listed below ® (Wyeth) Injection, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier), net price 0.5-mL vial = £10.20 ACT-HIB ® (Aventis Pasteur MSD Ltd) Injection, powder for reconstitution, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier), net price per vial with diluent (0.5 mL) = £8.83With diphtheria, tetanus and pertussis vaccines
Each combined product may be used to complete a course started with any other combined product listed below; important see also under Adsorbed Diphtheria, Tetanus and Pertussis Vaccine ( under DIPHTHERIA VACCINES)ACT-HIB ®DTP
dc (Aventis Pasteur MSD Ltd) Injection, powder for reconstitution, capsular polysaccharide of Haemophilus influenzae type b (conjugated to a protein carrier) with diluent containing diphtheria toxoid, tetanus toxoid and Bordetella pertussis cells, net price per dual-chamber prefilled syringe = £10.41Hepatitis A
Single component:
Avaxim ® (Aventis Pasteur MSD Ltd) Injection, suspension of formaldehyde-inactivated hepatitis A virus (GBM grown in human diploid cells) 320 antigen units/mL adsorbed onto aluminium hydroxide, net price 0.5-mL prefilled syringe = £20.63
Havrix Monodose
® (Glaxo SmithKline) Injection, suspension of formaldehyde-inactivated hepatitis A virus (HM 175 grown in human diploid cells) 1440 ELISA units/mL adsorbed onto aluminium hydroxide, net price 1-mL prefilled syringe = £23.81, 0.5-mL (720 ELISA units) prefilled syringe (Havrix Junior Monodose®) = £18.03With hepatitis b:
Twinrix ® (Glaxo SmithKline) Injection, inactivated hepatitis A virus 720 ELISA units and recombinant (DNA) hepatitis B surface antigen 20 micrograms/mL adsorbed onto aluminium hydroxide and aluminium phosphate, net price 1-mL prefilled syringe (Twinrix® Adult) = £29.85, 0.5-mL prefilled syringe (Twinrix® Paediatric) = £22.36
With typhoid vaccine:
Hepatyrix ® (Glaxo SmithKline) Injection, suspension of inactivated hepatitis A virus (grown in human diploid cells) 1440 ELISA units/mL adsorbed onto aluminium hydroxide, combined with typhoid vaccine containing 25 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 1-mL prefilled syringe = £34.49
Hepatitis b vaccine
Single component:
Engerix B ® (Glaxo SmithKline) Injection, suspension of hepatitis B surface antigen (rby, prepared from yeast cells by recombinant DNA technique) 20 micrograms/mL adsorbed onto aluminium hydroxide, net price 0.5-mL (paediatric) vial = £9.85, 1-mL vial = £13.27, 1-mL prefilled syringe = £13.97
(Aventis Pasteur MSD Ltd) Injection, suspension of hepatitis B surface antigen (prepared from yeast cells by recombinant DNA technique) 10 micrograms/mL adsorbed onto aluminium hydroxide, net price 1-mL prefilled syringe = £12.13, 1-mL vial = £11.41, 0.5-mL prefilled syringe (HB-Vax® II Paediatric) = £8.99 Excipients: include thiomersal With hepatitis A vaccine See Hepatitis A VaccineInfluenza vaccines:
Inactivated Influenza Vaccine (Split Virion) (Aventis Pasteur MSD Ltd) Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £5.70 Excipients: include thiomersal
Inactivated Influenza Vaccine (Surface Antigen) (Evans Vaccine) Injection, suspension of propiolactone-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £3.98 Excipients: include thiomersal Begrivac ® (Wyeth) Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £5.72 Fluarix ® (Glaxo SmithKline) Injection, suspension of formaldehyde-inactivated influenza virus (split virion) Flu/Vac/Split, net price 0.5-mL prefilled syringe = £3.99 Excipients: include thiomersalFluvirin ® (Evans Vaccine) Injection, suspension of propiolactone-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £5.69Excipients: include thiomersal
Influvac Sub-unit ® (Solvay Healthcare Ltd ) Injection, suspension of formaldehyde-inactivated influenza virus (surface antigen) Flu/Vac/SA, net price 0.5-mL prefilled syringe = £5.08 Excipients: include thiomersal Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL as a single dose; CHILD 6–35 months 0.25–0.5 mL repeated after at least 4 weeks if child not previously infected or vaccinatedMeasles vaccines:
Single antigen
Single antigen vaccine No longer available in the UK
Combined vaccine:
MMR Vaccine Live measles, mumps, and rubella vaccine Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL Available from Health Authorities or (in England only) direct from Farillon as MMR II® (Aventis Pasteur MSD Ltd) or Priorix® (SmithKline Beecham)
Meningococcal vaccines
Meningitec (Wyeth) Injection, suspension of capsular
polysaccharide antigen of Neisseria meningitidis group C (conjugated to Corynebacterium
diphtheriae protein), net price 0.5-mL vial = £17.95
Menjugate ® (Chiron)
Injection, powder for reconstitution, capsular polysaccharide antigen of Neisseria
meningitidis group C (conjugated to
Corynebacterium diphtheriae protein), adsorbed onto aluminium hydroxide, single-dose and
10-dose vials
NeisVac-C ® (Baxter) Injection, suspension of polysaccharide antigen of Neisseria meningitidis group C (conjugated to tetanus toxoid protein), 0.5-mL prefilled syringe
AC Vax ® (Glaxo SmithKline) Injection, powder for reconstitution, capsular polysaccharide antigens of Neisseria meningitidis groups A and C, net price single-dose vial (with diluent) = £7.37
Mengivac (A+C) ® (Aventis Pasteur MSD Ltd)
Injection, powder for reconstitution, capsular polysaccharide antigens of Neisseria
meningitidis (meningococcus) groups A and C, net price single-dose vial (with syringe
containing diluent) = £6.39
ACWY Vax ® (Glaxo SmithKline) Injection,
powder for reconstitution, capsular polysaccharide antigens of Neisseria meningitidis
groups A, C, W135 and Y, net price single-dose vial (with diluent) = £17.14
pneumococcal vaccine:
Pneumococcal polysaccharide vaccines
Pneumovax II (Aventis Pasteur MSD Ltd) Polysaccharide from each of 23 capsular types of pneumococcus, net price 0.5-mL prefilled syringe = £10.00 Dose: by subcutaneous or intramuscular injection, 0.5 mL; revaccination, see notes above; CHILD under 2 years, not recommended (suboptimal response and also safety and efficacy not established)
Pnu-Imune ® (Wyeth) Polysaccharide from each of 23 capsular types of pneumococcus, net price 0.5-mL vial = £9.94 Excipients: include thiomersal Dose: by subcutaneous or intramuscular injection, 0.5 mL; revaccination, see notes above; CHILD under 2 years, not recommendedPneumococcal polysaccharide conjugated vaccine
Prevnar ® (Wyeth) Polysaccharide from each of 7 capsular types of pneumococcus adsorbed onto aluminium phosphate, net price 0.5-mL vial = £39.25 Dose: by intramuscular injection, INFANT under 6 months 3 doses each of 0.5 mL separated by intervals of 1 month and a further dose in second year of life; 6 months–1 year 2 doses each of 0.5 mL separated by an interval of 1 month and a further dose in second year of life; CHILD 1–2 years 2 doses each of 0.5 mL separated by an interval of 2 monthsPolio vaccines
Live (oral) (Sabin)
Poliomyelitis Vaccine, Live (Oral) Pol/Vac (Oral)1. A suspension of suitable live attenuated strains of poliomyelitis virus, types 1, 2, and 3. Available in single-dose and 10-dose containers Dose: 3 drops from a multidose container or the total contents of a single-dose container; for primary immunisation 3 doses are required (see schedule, section 14.1). May be given on a lump of sugar; not to be given with foods which contain preservatives Available from Health Authorities or (in England and Scotland only) direct from Farillon 1. BP permits code OPV for vaccine in single doses provided it also appears on pack. Note. Poliomyelitis vaccine loses potency once the container has been opened, therefore any vaccine remaining at the end of an immunisation session should be discarded; whenever possible sessions should be arranged to avoid undue wastage.Inactivated (Salk)
Poliomyelitis Vaccine, Inactivated Pol/Vac (Inact). An inactivated suspension of suitable strains of poliomyelitis virus, types 1, 2, and 3. Dose: by subcutaneous injection, 0.5 mL or as stated on the label; for primary immunisation 3 doses are required at intervals of 4 weeks Available direct from Farillon. Note. Should be ordered one dose at a time (on a named-patient basis) and only when required for useRabies vaccine:
Rabies Vaccine (Aventis Pasteur MSD Ltd) Freeze-dried inactivated Wistar rabies virus strain PM/WI 38 1503-3M cultivated in human diploid cells, net price single-dose vial with syringe containing diluent = £22.15 IMPORTANT. Studies have shown that when this vaccine is injected into the gluteal region there is a poor response. Concomitant administration of chloroquine may also affect the antibody response. Because of the potential consequences of inadequately treated rabies exposure and because there is no indication that fetal abnormalities have been associated with rabies vaccination, pregnancy is not considered a contra-indication to post-exposure prophylaxis. If there is substantial risk of exposure to rabies, pre-exposure prophylaxis may also be indicated during pregnancy
Rabipur ®
(MASTA) Freeze-dried inactivated Flury LEP rabies virus strain cultivated in chick embryo cells, net price single-dose vial = £22.15 Dose: prophylactic, by intramuscular injection in the deltoid muscle or anterolateral thigh in small children, 1 mL on days 0, 7 and 21 or 28; also booster doses every 2–5 years for those at continued riskRubella vaccine:
Rubella Vaccine, Live Rub/Vac (Live). Prepared from Wistar RA 27/3 strain propagated in human diploid cells Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL (see schedule, section 14.1 and notes above) Available from Health Authorities or (in England only) direct from Farillon as SmithKline Beecham brand (Ervevax®)
Tetanus vaccines:
Adsorbed Tetanus Vaccine Tet/Vac/Ads. Injection, suspension of tetanus formol toxoid adsorbed on a mineral carrier Dose: by deep subcutaneous or by intramuscular injection, 3 doses each of 0.5 mL separated by intervals of 1 month Available from Evans Vaccines as Clostet®, net price 0.5-mL single-dose syringe = £1.40) and from Aventis Pasteur MSD Ltd Aventis Pasteur (net price 0.5-mL amp = 74p; 0.5-mL single-dose syringe = £1.50; excipients include thiomersal
Typhoid vaccines:
Polysaccharide vaccine for injection
Typherix ®
(Glaxo SmithKline) Injection, Vi capsular polysaccharide typhoid vaccine, 50 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 0.5-mL prefilled syringe = £10.68 Dose: by intramuscular injection, 0.5 mL; CHILD under 2 years may show suboptimal responseTyphim
Vi ® (Aventis Pasteur MSD Ltd ) Injection, Vi capsular polysaccharide typhoid vaccine, 50 micrograms/mL virulence polysaccharide antigen of Salmonella typhi, net price 0.5-mL prefilled syringe = £10.20 Dose: by deep subcutaneous or by intramuscular injection, 0.5 mL; CHILD under 18 months may show suboptimal responsePolysaccharide vaccine with hepatitis A vaccine See Hepatitis A Vaccine
Live oral vaccine
Vivotif ® (MASTA)
Capsules, e /c, live attenuated Salmonella typhi (Ty 21a), net price 3-cap pack = £15.88. Label: 23, 25, C, administration dose: ADULT and CHILD over 6 years, 1 capsule on days 1, 3, and 5; under 6 years, not recommended COUNSELLING. Swallow as soon as possible after placing in mouth with a cold or lukewarm drink; it is important to store capsules in refrigeratorYellow Fever Vaccine
Yellow Fever Vaccine, Live Yel/Vac. A suspension of chick embryo proteins containing attenuated 17D strain virusDose: by subcutaneous injection, 0.5 mL Available (only to designated Yellow Fever Vaccination centres) as Arilvax® (Evans Vaccine)