Quadracel and Act-HIB (Polio IPV, tetanus, Haemophilus b, Pertussis, Diptheria)
Aventis Pasteur MSD Ltd
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Edda West from VRAN (Canada) on 5 in 1 vaccine (Pentacel)
Vaccine Notes & Ingredients:
Both inactivated (IPV) and live oral (OPV) poliovirus vaccines are licensed for use in Canada, but because of the risk of vaccine associated paralytic polio, only IPV is recommended for routine use. IPV is contained in Pentacel.
Starting at two months of age, Canadian infants are injected with a five in one vaccine called Pentacel that is a comarketing of 2 vaccines, Quadracel and Act-HIB.
Pentacel ingredients: Lyophilized Haemophilus b Conjugate Vaccine (bound to
tetanus protein) -- Act HIB, and is to be reconstituted with Component Pertussis Vaccine
and Deiphteria and Tetanus Toxoids Adsorbed combined with Inactivated Poliomyelitis
Vaccine -- Quadracel.
- Each .05 ml. dose of Act-HIB contains purified capsular polysaccharide covalently bound to tetanus protein .
- Each .05 ml. dose of Quadracel contains pertussis toxoid, filamentous hemagglutinin, fimbriae, pertactin(a membrane protein), diphtheria toxoid, tetanus toxoid(inactivated with formaldehyde), aluminum(.33mg), purified inactivated poliomyelitis vaccine: Type 1(Mahoney); Type 2(M.E.F.1); Type 3(Saukett); and 2-phenoxyethanol 0.6% + 0.1% added as preservative. The vaccine also contains 20 ppm Tween 80, less than 0.05% human albumin, and less than 1 ppm bovine serum. Trace amounts of polymyxin B and neomycin may be present from the cell growth medium. The three poliovirus types are inactivated by formalin (formaldehyde) and are grown on human diploid cells derived originally from aborted human fetuses. (Source: Compendium of
Pharmaceuticals and Specialties 1999)