[back] Synergistic toxicity
More on Thimerosal & things that synergistically increase the toxicity
"The elderly are more susceptible than young adults because of decreased
levels of protective glutathione and melatonin. "
I would add tylenol use too because it depletes glutathione, even further,
which is necessary to remove mercury...........Sheri
What Is a Toxic Dose?
Dr. Haley declines to state a toxic level of mercury because patients
differ in their ability to detoxify and excrete the mercury. Also, many
factors synergistically increase the toxicity of a given level. These
1. Antibiotics. Both ampicillin and tetracycline have been shown to enhance
the neuron-killing effect of thimerosal, perhaps by enhancing its delivery
to specific sites.
2. Aluminum and formaldehyde (also found in vaccines).
3. Other heavy metals (Pb, Cd, Zn). Lead plus mercury has an effect 50
times that predicted from simply adding the individual effects. Smokers
have a high level of cadmium. Zinc is an essential element, normally
present in the body, and is also found in dental amalgam.
4. Periodontal disease. Anaerobic mouth bacteria react with
amalgam-generated Hg+2 to produce organo-mercury compounds. Could this help
explain why periodontal disease is a risk factor for stroke, heart disease,
and late-onset insulin-dependent diabetes mellitus?
5. EDTA. Chelation with EDTA, which is very common in American foods,
actually potentiates the effect of Hg+2 on the polymerization of tubulin in
neurons (Duhr EF et al. Toxicol & Applied Pharmacol 1993;122:273-280.)
The elderly are more susceptible than young adults because of decreased
levels of protective glutathione and melatonin.
Genetic susceptibility is critical. Carriers of brain protein APO-E2 are
relatively protected, and carriers of APO-E4 are at enhanced risk of
Alzheimer's disease, possibly because the former has two additional thiol
groups capable of binding and removing mercury.
The FDA and other regulatory agencies routinely dismiss basic research
showing the unique toxicity of mercury at very low concentrations, notes
Dr. Haley. Moreover, there is a paucity of NIH funds to study potential
neurotoxicity at the doses used in medicine and dentistry. Organizations
such as the ADA can then cite the lack of ``valid'' studies proving harm.
The ADA notes that amalgam has been used for 150 years and thus has a
record of safety. However, Dr. Haley points out that in the early 1900s,
the average life expectancy was about 50 years, much younger than the
average age of onset of Alzheimer's disease. Moreover, since amalgams only
became available to most working class Americans in the 1950s, baby boomers
are the ``great ongoing amalgam experiment.''
Using data from the Vaccine Adverse Event Reporting System (VAERS)
maintained by the CDC and from the 2001 U.S. Department of Education
report, a strong correlation was found between dosage of thimerosal from
childhood vaccines and the incidence of autism, speech disorders, and
cardiac arrest, but not with common vaccine reactions such as fever, pain,
and vomiting, or with other common childhood disabilities (Geier MR, Geier
DA, Medical Sentinel, in press).