Vaccines and Immune Suppression
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Vaccines and neonatal immune development
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Babies put at risk by vaccines Evidence of serious health consequences was recently confirmed in the Journal of Pediatrics in which CRP levels were measured after vaccination. CRP, short for C-reactive protein, is a blood marker indicating a heightened state of inflammation throughout the body.

[NVIC] Can DPT/DTaP Alter Immune Function?

"Dr. H.H. Fudenberg, world-renowned immunologist with hundreds of publications to his credit, made the following comments: “One vaccine decreases cell-mediated immunity by 50%, two vaccines by 70%…all triple vaccines (MMR, DTaP) markedly impair cell-mediated immunity, which predisposes to recurrent viral infections, especially otitis media, as well as yeast and fungi infections.”--Harold E. Buttram, MD; Susan Kreider, RN; Alan R. Yurko

Farhad Imani1,  Kelly E. Kehoe.  Infection of Human B Lymphocytes with MMR Vaccine Induces IgE Class Switching pp. 355-361 (doi:10.1006/clim.2001.5073) Division of Clinical Immunology, Department of Medicine, The Johns HopkinsUniversity School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, Maryland, 21224 (Received February 26, 2001; accepted May 24, 2001; published electronically July 26, 2001)
Circulating immunoglobulin E (IgE) is one of the characteristics of human allergic diseases including allergic asthma. We recently showed that infection ofhuman B cells with rhinovirus or measles virus could lead to the initial steps of  IgE class switching. Since many viral vaccines are live viruses, we speculated  that live virus vaccines may also induce IgE class switching in human B cells.  To examine this possibility, we selected the commonly used live attenuated measles mumps rubella (MMR) vaccine. Here, we show that infection of a human IgM+ B cell line with MMR resulted in the expression of germline  transcript. In addition, infection of freshly prepared human PBLs with this vaccine resulted in the expression of mature IgE mRNA transcript. Our data suggest that a potential side effect of vaccination with live attenuated viruses may be an increase in the expression of IgE. Copyright 2001 Academic Press.

Auwaerter PG, Hussey GD, Goddard EA, Hughes J, Ryon JJ, Strebel PM, Beatty D, Griffin DE.   Changes within T cell receptor V beta subsets in infants following measles vaccination. Clin Immunol Immunopathol. 1996 May;79(2):163-70. PMID: 8620622
Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients.... [The following citation, Martinez X et al.,reiterates that vaccinations can impair cell-mediated immunity by shifting cytokines release into a Th2 pattern, thereby allowing intracellular pathogens (eg, many viruses) to be more successful. We note that the authors of this 1997 study are trying to devise a way around the general immune-impairing effect of conventional vaccinations.]--Teresa Binstock

Beckenhauer, W H, et al, "Immunosuppression with Combined Vaccines", J AM Vet Med Assoc, Aug 15, 1983, 183(4):389-390.

Blumberg DA, "Leukocyte responses to diphtheria-tetanus- pertussis and diphtheria-tetanus immunization", Pediatr Infect Dis J 1991 Mar; 10(3):247-248.

Bastin, R et al, "Repeated Cholera Vaccination Immunological "Depressive" effect," Ann Med Interne (Paris), Jun-July 1974, 125(6-7):513-518.

Castan, P et al, "Coma Revealing an acute Leukosis in a child, 15 days after an Oral Anti-poliomyelitis Vaccination," Acta Neurol Bekg, May 1965, 65:349-367.

Dankova E, et al.  [Immunologic findings in children with abnormal reactions after vaccination]. Cesk Pediatr. 1993 Jan;48(1):9-12. Czech.PMID: 8477472; UI: 93238311.

Daniliuk, O S et al, "Immunodepressive action Vaccinia  Virus", Biull Eksp Biol Med, Jul 1982, 94(7):73-74.

Ehrland, W, "Susceptibility to Infection After Vaccination", Br Med J, Mar 11, 1972, 1:683.

Eibl MM, Mannhalter JW, Zlabinger G.  Abnormal T-lymphocyte subpopulations in healthy subjects after tetanus booster immunization.N Engl J Med. 1984 Jan 19;310(3):198-9. No abstract available.PMID: 6228737 [PubMed - indexed for MEDLINE]
"As reported in a letter to the New England Journal of Medicine in 1984, tests of T-lymphocyte subpopulations were done on 11 healthy adults before-and-after routine tetanus booster immunizations. Tests showed a significant though temporary drop in T-helper lymphocytes (a class of white blood cells which helps govern the immune system) in all of the subjects. Special concern rests in the fact that in 4 of the subjects the T-helper cells fell to levels found in active AIDS patients. (2) If this was the result of a single vaccine in healthy adults, it is sobering to think of the consequences of the multiple vaccines (twenty-one at last count) routinely given to infants with their immature systems during the first six months of life. However, we can only speculate as to the consequences, as this test has never been repeated."--Dr Buttram MD

Fattom, A, Cho, Y.H, Chu, C.Y, Fuller, S, Fries, L, Naso, R, "Vaccines May Cause Immune Suppression ....", Vaccine, Jan 1999;17(2):126-133.
Futton, A et al, "Vaccines May Cause Immune Suppression", Vaccine, Jan 1999, 17(2):126-133.

Green, MS, et al , "Depression of Immune Response to an Inactivated Hepatitis A Vaccine Administered Concomitantly with Immune Globulin", J Infect Dis, 1993 Sep; 168(3):740-743.

Hussey GD, Goddard EA, Hughes J, Ryon JJ, Kerran M, Carelse E, Strebel PM, Markowitz LE, Moodie J, Barron P, Latief Z, Sayed R, Beatty D, Griffin DE.  The effect of Edmonston-Zagreb and Schwarz measles vaccines on immune response in infants. J Infect Dis. 1996 Jun;173(6):1320-6. PMID: 8648203
Eighty-eight children were immunized at 6 or 9 months of age with the Edmonston-Zagreb (EZ) or Schwarz (SW6, SW9) strain of measles vaccine. Children were studied before and 2 weeks and 3 months after immunization. ...Mitogen-induced lymphoproliferation was decreased at 2 weeks in the SW9 group and at 3 months in all groups and was negatively correlated with measles antibody level at 3 months (r = -.387, P = .003). CD8 T cells, soluble CD8, neopterin, and beta2-microglobulin were increased at 2 weeks in the SW9 group, and soluble CD8 and beta2-microglobulin remained elevated at 3 months. Therefore, measles immunization resulted in suppression of lymphoproliferation, which was most evident in infants with the highest antibody responses and most immune activation.


Kumar, L et al, "Cell-Mediated Immuno-deficiency with Normal Immunoglobulins (Nezelof’s Syndrome) with Progressive Vaccinia", Indian Pediatr, Jan 1977, 14 (1):69-72.

Kotwal, G j et al, "Inhibition of the Complement Cascade by the Major Secretory Protein of Vaccinia Virus", Science, Nov 9, 1990, 250(4982):827-830.

Martinez X et al. DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life. Proc of the National Academy of Sciences 94.8726-31 1997. ab: The relative deficiency of T helper type 1 (Th1) and cytotoxic T lymphocyte (CTL) responses in early life is associated with an increased susceptibility to infections by intracellular microorganisms. This is likely to reflect a preferential polarization of immature CD4 T cells toward a Th2 rather than a Th1 pattern upon immunization with conventional vaccines...

Munyer, et al, "Depressed Lymphocyte Function after Measles-Mumps-Rubella Vaccination", Jour Infection Disorder, vol 132, No 1, July 1975, p 75-80.

Nakayama T, Urano T, Osano M, Maehara N, Sasaki K, Makino S. Long-term regulation of interferon production by lymphocytes from children inoculated with live measles virus vaccine. J Infect Dis. 1988 Dec;158(6):1386-90. No abstract available. PMID: 3143767
In the study, one-year-old infants were vaccinated with the measles vaccine. This caused a huge drop in the level of alpha-interferon produced by  lymphocytes. Not only that, this harmful reduction in interferon production  lasted for an entire year, at which time the experiment was ended. Conclusion: The study showed that the measles vaccine produced a significant long-term immune suppression.

Oski and Naiman, "Effect of Live Measles Vaccine on the Platelet Count", NEJM, Aug 18, 1966, p 352-356.
Reik, L Jr, "Disseminated Vasculomyelinopathy: An Immune Complex Disease", Ann Neurol, Apr 1980, 7(4):291- 296.

Pletsityl, DF, et al, "The Effect of the Vaccinal Process on the Non-specific Phagocytic Activity of Peripheral Blood Leukocytes", Biull Eksp Biol Med, Mar 1973, 75(3):76-79.

Strauss, J et al, "Loss of Maternal Measles Antibodies Acquired By Vaccination Against Measles," Cesk epidemiol Mikrobiol Immunol, May 1991, 40(3):137-143.

Stickl, H, "Iatrogenic Immunosuppression as a Result of Vaccination", Fortschr Med, Mar 5, 1981, 99(9):289-292.
Children", Acta Paediatr, 1992 Nov; 81(11):887-890.

Toraldo, R, et al, "Effect of Measles-Mumps-Rubella Vaccination on Polymorphonuclear Neutrophil Functions in

Wilkins and Wehrle, "Additional Evidence Against Measles Vaccine Administration to Infants Less than 12 months of Age: Altered Immune Response Following Active- Passive Immunization, Jour Ped, 1979, Vol 94, p 865-869.

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