Rubella vaccine adverse reactions
Rubella vaccine

Austin SM, et al.    Joint reactions in children vaccinated against rubella. I. Comparison of two vaccines. Am J Epidemiol. 1972 Jan;95(1):53-8. No abstract available.PMID: 5061698; UI: 72080684. 

Bartos HR.  Thrombocytopenia associated with rubella vaccination. N Y State J Med. 1972 Feb 15;72(4):499. No abstract available.PMID: 4501388; UI: 72119111  

Behan PO.      Diffuse myelitis associated with rubella vaccination [letter]. Br Med J. 1977 Jan 15;1(6054):166. No abstract available.PMID: 832049; UI: 77088653.

Cooper LZ, Ziring PR, Weiss HJ, Matters BA, Krugman S.Transient arthritis after rubella vaccination.Am J Dis Child. 1969 Aug;118(2):218-25. No abstract available.PMID: 5794817 [PubMed - indexed for MEDLINE]

Delaney JJ.      Problems of rubella vaccination in adult women. Rocky Mt Med J. 1970 Oct;67(10):53-6. No abstract available.PMID: 5472053; UI: 71010716.

Geier DA, Geier MR.   A one year followup of chronic arthritis following rubella and hepatitis B vaccination based upon analysis of the Vaccine Adverse Events Reporting System (VAERS) database.   Clin Exp Rheumatol 2002 Nov-Dec;20(6):767-71.   MedCon, Inc., Silver Spring, Maryland, USA.

OBJECTIVES: This analysis examined the incidence rate of chronic arthritis adverse reactions reported following adult rubella and hepatitis B vaccinations. In this analysis, etiologic mechanisms for chronic arthritis following adult rubella and hepatitis B vaccines were also explored. METHODS: The Vaccine Adverse Events Reporting System (VAERS) database was analyzed for the incidence rate of reported cases of chronic arthritis in comparison to Tetanus-diphtheria (Td) and tetanus toxoid adult vaccine control groups. RESULTS: Chronic arthritis adverse reactions following adult rubella vaccination were primarily reported in females (female/male ratio = 3.0), at about 45 years-old, and at a mean onset time of 10-11 days following vaccination. Chronic arthritis adverse reactions following adult hepatitis B vaccination were also primarily reported in females(female/male ratio = 3.5), at about 33 years-old, and with a mean onset time of 16 days following vaccination. The incidence rates of chronic arthritis following adult rubella and adult hepatitis B vaccinations were statistically significantly increased, by chi 2 analysis, in comparison to the adult vaccine control groups. The attributable risk of chronic arthritis following adult rubella vaccine ranged from 32 to 53 and from 5.1 to 9.0 following adult hepatitis B vaccine in comparison to the adult vaccine control groups. CONCLUSION: This study revealed that adult rubella and adult hepatitis B vaccines were statistically associated with chronic arthritis which persisted for at least one year. The etiology for these adverse reactions may involve autoimmune mechanisms. Furthermore, potential biases in the reporting rates of adverse reactions to VAERS were not observed.   PMID: 12508767 [PubMed - in process]

Gold JA. Arthritis after rubella vaccination of women. N Engl J Med. 1969 Jul 10;281(2):109. No abstract available.PMID: 5784773; UI: 69205374.

Howson CP, et al. Chronic arthritis after rubella vaccination. Clin Infect Dis. 1992 Aug;15(2):307-12. Review. PMID: 1520764; UI: 92392957

Hulbert TV, et al.   Bilateral hearing loss after measles and rubella vaccination in an adult. N Engl J Med. 1991 Jul 11;325(2):134. No abstract available.PMID: 2052052; UI: 91270316.

Kilroy AW, Schaffner W, Fleet WF Jr, Lefkowitz LB Jr, Karzon DT, Fenichel GM.Two syndromes following rubella immunization. Clinical observations and epidemiological studies.JAMA. 1970 Dec 28;214(13):2287-92. No abstract available.PMID: 5536887 [PubMed - indexed for MEDLINE]

Kline LB, et al. [See Related Articles] Optic neuritis and myelitis following rubella vaccination. Arch Neurol. 1982 Jul;39(7):443-4. No abstract available.PMID: 7103782; UI: 82256057.

Mitchell LA, et al. HLA-DR class II associations with rubella vaccine-induced joint manifestations. J Infect Dis. 1998 Jan;177(1):5-12. PMID: 9419163; UI: 98078972.

Moss JT.        Reactions to rubella vaccinations. Aust Fam Physician. 1986 Dec;15(12):1543, 1546. No abstract available.PMID: 3800771; UI: 87099584.

Muhlebach-Sponer M, et al.   Intrathecal rubella antibodies in an adolescent with Guillain-Barre syndrome after mumps-measles-rubella vaccination. Eur J Pediatr. 1995 Feb;154(2):166. No abstract available.PMID: 7720751; UI: 95237246.

Nakazono N, et al.Factors associated with clinical reactions to rubella vaccination in women. Int J Gynaecol Obstet. 1987 Jun;25(3):207-16. PMID: 2886379; UI: 87276843.

Polk BF, et al A controlled comparison of joint reactions among women receiving one of two rubella vaccines. Am J Epidemiol. 1982 Jan;115(1):19-25. Review. PMID: 7034531; UI: 82110889.
Peters ME, et al. Bone changes after rubella vaccination. AJR Am J Roentgenol. 1984 Jul;143(1):27-8. No abstract available. PMID: 6610325; UI: 84228049.

Ray, P, et al. Risk of chronic arthropathy among women after rubella vaccination. Vaccine Safety Datalink Team. JAMA. 1997 Aug 20;278(7):551-6. PMID: 9268275; UI: 97412162.

Spruance SL, et al. Chronic arthropathy associated with rubella vaccination. Arthritis Rheum. 1977 Mar;20(2):741-7. PMID: 849368; UI: 77157350.
Stevenson VL, et al. Optic neuritis following measles/rubella vaccination in two 13-year-old children. Br J Ophthalmol. 1996 Dec;80(12):1110-1. No abstract available.PMID: 9059281; UI: 97212425.

Speier JE.Complications of rubella vaccination.JAMA. 1970 Sep 28;213(13):2272. No abstract available.PMID: 5468941 [PubMed - indexed for MEDLINE]

Thompson GR, Weiss JJ, Shillis JL, Brackett RG.Intermittent arthritis following rubella vaccination. A three-year follow-up.Am J Dis Child. 1973 Apr;125(4):526-30. No abstract available.PMID: 4699891 [PubMed - indexed for MEDLINE]

Tingle AJ, Chantler JK, Pot KH, Paty DW, Ford DK.Postpartum rubella immunization: association with development of prolonged arthritis, neurological sequelae, and chronic rubella viremia.J Infect Dis. 1985 Sep;152(3):606-12.PMID: 4031558 [PubMed - indexed for MEDLINE]

Tingle AJ, et al. Randomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative women. Lancet. 1997 May 3;349(9061):1277-81. PMID: 9142061; UI: 97286969.

Vejtorp M, Leerhoy J.[The risk of rubella-induced fetal damage].Ugeskr Laeger. 1978 Aug 21;140(34):2031-4. Danish. No abstract available.PMID: 98886; UI: 78251602
Weibel RE (1996)., et al Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the National Vaccine Injury Compensation Program. Arthritis Rheum. 1996 Sep;39(9):1529-34. PMID: 8814065; UI: 96409082.

Wallace RB, Libert P, Ibrahim M, Isacson P.Joint symptoms following an area-wide rubella immunization campaign--report of a survey.Am J Public Health. 1972 May;62(5):658-61. No abstract available.PMID: 5024291 [PubMed - indexed for MEDLINE]

Rubella vaccine linked to Epstein-Barr Virus—Dr Mendelsohn MD (1987)

GBS 18 years following rubella vaccine

The Chronic Rubella Viremia
Support Group, South 20655 Brown Rd., Cataldo ID 83810, (208) 689-3925...

The Chronic Rubella Viremia Support Group is a group of over 200 health care professionals who submitted to rubella vaccination and ended up with chronic debilitating symptoms attributable to rubella vaccine.  The founder of the group, Katy Fox, RN, suspects that many other health professionals were adversely affected by the rubella vaccine.  When 20/20 did a story on the subject, she says, over 600 people responded.

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