Human studies A-Z
Citations re electromagnetic radiation
Borbely A.A. et al. Pulsed high-frequency electromagnetic field affects human sleep and sleep electroencephalogram. Neurosci. Lett. 1999; 275(3): 207-210.
Goldsmith JR.
Epidemiologic evidence relevant to radar
(microwave) effects. Environ
Health Perspect. 1997 Dec;105 Suppl 6:1579-87. Review. PMID: 9467086 [PubMed -
indexed for MEDLINE]
Public and occupational exposures
to microwave (RF) radiation are of two main types. The first type of exposures
are those connected with military and industrial uses and, to some extent,
broadcast exposures. It is this type that most of the data cited in this study
draw upon. The second type, cellular telephones and their associated broadcast
requirements, have raised concerns about current exposures because of their
increasingly widespread use. Four types of effects were originally reported
in multiple studies: increased spontaneous abortion, shifts in red and white
blood cell counts, increased somatic mutation rates in lymphocytes, and
increased childhood, testicular, and other cancers. In addition, there is
evidence of generalized increased disability rates from a variety of causes in
one study and symptoms of sensitivity reactions and lenticular opacity in at
least one other. These findings suggest that RF exposures are potentially
carcinogenic and have other health effects. Therefore, prudent avoidance of
unneeded exposures is recommended as a precautionary measure. Epidemiologic
studies of occupational groups such as military users and air traffic
controllers should have high priority because their exposures can be reasonably
well characterized and the effects reported are suitable for epidemiologic
monitoring. Additional community studies are needed. -- Environ Health
Perspect 105(Suppl 6):1579-1587 (1997)
http://ehp.niehs.nih.gov/members/1997/Suppl-6/goldsmith-full.html
http://www.mindfully.org/Technology/Microwave-Effects-Goldsmith1dec97.htm
Goldsmith JR. Epidemiologic Evidence of
Radiofrequency Radiation (Microwave) Effects on Health in Military,
Broadcasting, and Occupational Studies.Int J Occup
Environ Health. 1995 Jan;1(1):47-57. PMID: 9990158 [PubMed - as supplied by
publisher]
In this opinion
piece, the author brings together and discusses the collective relevance of
possible health effects of microwave or radar exposure in military,
broadcasting, and occupational circumstances, with a view to assuring optimal
protective practices. Sources of the information presented include 1) historical
data, 2) experiences of Polish soldiers, 3) a study of U.S. naval personnel
using radar in the Korean War, 4) preliminary findings of exposures to the
Skrunda, Latvia, transmitter, 5) data obtained near Hawaiian broadcasting
facilities, 6) occupational studies of electronic and electrical workers,
including ham radio operators, 7) reproductive outcomes among physiotherapists
using short-wave and microwave diathermy, and 8) U.S. foreign service personnel
exposed at Embassies in Eastern Europe. Some of the data are available in the
peer-reviewed literature, others in abstracts, reports, or other
non-peer-reviewed forms. Some were obtained under Freedom of Information
statutes and are incomplete. For some of these, there is reason to believe that
further evidence desired by the investigator was not obtained. Some are
case-referent studies, but most are not. Some are ecological, and all are
retrospective. Few have reliable dose estimations, and none has accurate dosage
information on each subject. None includes evidence of tissue heating or any
short-term effect. Possible outcomes considered included 1) blood count changes,
2) evidence of somatic mutation, 3) impairment of reproductive outcomes,
especially increased spontaneous abortion, and 4) increase in cancer incidence
and mortality, especially of the hematopoietic system, brain, and breast. The
author presents evidence that sufficient microwave exposures are associated with
all four of these outcomes, concluding that the possible effects and their
timings with respect to exposure are qualitatively similar to those on ionizing
radiation. A prudent course of action would be to provide more protection for
those exposed than required by present regulations. No systematic effort to
include negative studies is made; thus this review has a positive reporting
bias.
Hocking B, Westerman R. Neurological effects of
radiofrequency radiation. Occup
Med (Lond). 2003 Mar;53(2):123-7. Review. PMID: 12637597 [PubMed - indexed for
MEDLINE]
BACKGROUND:
The health effects of radiofrequency radiation (RFR) and the adequacy of the
safety standards are a subject of debate. One source of human data is case
reports regarding peripheral neurological effects of RFR, mainly noxious
sensations or dysaesthesiae. AIM: To investigate health effects,
neurophysiological mechanisms and safety levels for RFR. METHODS: We conducted a
literature search for case reports and case series associated with mobile phone
technology as well as other RFR sources using specific search terms on PubMed.
RESULTS: We identified 11 original articles detailing case reports or case
series and matching the search criteria. Five of the identified papers were
written by at least one of the authors (B.H. or R.W.). CONCLUSIONS: Cases have
arisen after exposure to much of the radiofrequency range. In some cases,
symptoms are transitory but lasting in others. After very high exposures, nerves
may be grossly injured. After lower exposures, which may result in dysaesthesia,
ordinary nerve conduction studies find no abnormality but current perception
threshold studies have found abnormalities. Only a small proportion of similarly
exposed people develop symptoms. The role of modulations needs clarification.
Some of these observations are not consistent with the prevailing hypothesis
that all health effects of RFR arise from thermal mechanisms.
Hocking B, Gordon I, Hatfield G. TV towers and childhood leukaemia (continued)Aust N Z J Public Health. 2000 Apr;24(2):216-7. No abstract available. PMID: 10790947 [PubMed - indexed for MEDLINE]
Hocking B, Gordon I, Hatfield G, Grain H.Re: "Cancer incidence near radio and television transmitters in Great Britain. I. Sutton Coldfield transmitter. II. All high power transmitters".Am J Epidemiol. 1998 Jan 1;147(1):90-1. No abstract available. PMID: 9440406 [PubMed - indexed for MEDLINE]
Hocking B, Gordon IR, Grain HL,
Hatfield GE. Cancer
incidence and mortality and proximity to TV towers.Med J
Aust. 1996 Dec 2-16;165(11-12):601-5. Erratum in: Med J Aust 1997 Jan
20;166(2):80. PMID: 8985435 [PubMed - indexed
for MEDLINE]
OBJECTIVE: To
determine whether there is an increased cancer incidence and mortality in
populations exposed to radiofrequency radiations from TV towers. DESIGN: An
ecological study comparing cancer incidence and mortality, 1972-1990, in nine
municipalities, three of which surround the TV towers and six of which are
further away from the towers. (TV radiofrequency radiation decreases with the
square of the distance from the source.) Cancer incidence and mortality data
were obtained from the then Commonwealth Department of Human Services and
Health. Data on frequency, power, and period of broadcasting for the three TV
towers were obtained from the Commonwealth Department of Communications and the
Arts. The calculated power density of the radiofrequency radiation in the
exposed area ranged from 8.0 microW/cm2 near the towers to 0.2 microW/cm2 at a
radius of 4km and 0.02 microW/cm2 at 12 km. SETTING: Northern Sydney, where
three TV towers have been broadcasting since 1956. OUTCOME MEASURES: Rate ratios
for leukaemia and brain tumour incidence and mortality, comparing the inner with
the outer areas. RESULTS: For all ages, the rate ratio for total leukaemia
incidence was 1.24 (95% confidence interval [CI], 1.09-1.40). Among children,
the rate ratio for leukaemia incidence was 1.58 (95% CI, 1.07-2.34) and for
mortality it was 2.32 (95% CI, 1.35-4.01). The rate ratio for childhood
lymphatic leukaemia (the most common type) was 1.55 (95% CI, 1.00-2.41) for
incidence and 2.74 (95% CI, 1.42-5.27) for mortality. Brain cancer incidence and
mortality were not increased. CONCLUSION: We found an association between
increased childhood leukaemia incidence and mortality and proximity to TV
towers.
A health survey was carried out in La Ñora, Murcia, Spain, in the vicinity of two GSM 900/1800 MHz cellular phone base stations. The E-field (~ 400 MHz – 3 GHz) measured in the bedroom was divided in tertiles (0.02 – 0.04 / 0.05 – 0.22 / 0.25 – 1.29 V/m). Spectrum analysis revealed the main contribution and variation for the E-field from the GSM base station. The adjusted (sex, age, distance) logistic regression model showed statistically significant positive exposure-response associations between the E-field and the following variables: fatigue, irritability, headaches, nausea, loss of appetite, sleeping disorder, depressive tendency, feeling of discomfort, difficulty in concentration, loss of memory, visual disorder, dizziness and cardiovascular problems. The inclusion of the distance, which might be a proxy for the sometimes raised "concerns explanation", did not alter the model substantially. These results support the first statistical analysis based on two groups (arithmetic mean 0,65 V/m versus 0,2 V/m) as well as the correlation coefficients between the E-field and the symptoms (Navarro et al, "The Microwave Syndrome: A preliminary Study in Spain", Electromagnetic Biology and Medicine, Volume 22, Issue 2, (2003): 161 – 169). Based on the data of this study the advice would be to strive for levels not higher than 0.02 V/m for the sum total, which is equal to a power density of 0.0001 µW/cm² or 1 µW/m², which is the indoor exposure value for GSM base stations proposed on empirical evidence by the Public Health Office of the Government of Salzburg in 2002.
Richter E, Berman T, Ben-Michael E, Laster R, Westin JB.
Cancer in radar technicians exposed to radiofrequency/microwave radiation:
sentinel episodes.
Int J Occup Environ Health. 2000 Jul-Sep;6(3):187-93. PMID:
10926722 [PubMed - indexed for MEDLINE]
Controversy exists concerning the
health risks from exposures to radiofrequency/microwave irradiation (RF/MW). The
authors report exposure-effect relationships in sentinel patients and their
co-workers, who were technicians with high levels of exposure to RF/MW
radiation. Information about exposures of patients with sentinel tumors was
obtained from interviews, medical records, and technical sources. One patient
was a member of a cohort of 25 workers with six tumors. The authors estimated
relative risks for cancer in this group and latency periods for a larger group
of self-reported individuals. Index patients with melanoma of the eye,
testicular cancer, nasopharyngioma, non-Hodgkin's lymphoma, and breast cancer
were in the 20-37-year age group. Information about work conditions suggested
prolonged exposures to high levels of RF/MW radiation that produced risks for
the entire body. Clusters involved many different types of tumors. Latency
periods were extremely brief in index patients and a larger self-reported group.
The findings suggest that young persons exposed to high levels of RF/MW
radiation for long periods in settings where preventive measures were lax were
at increased risk for cancer. Very short latency periods suggest high risks from
high-level exposures. Calculations derived from a linear model of dose-response
suggest the need to prevent exposures in the range of 10-100 microw/cm(2).
Sobel and Davanipour (1996) outline the etiological process they hypothesize by which EMR produces Alzheimer's disease. The first step involves EMR exposure upsetting the cellular calcium ion homeostasis through calcium ion efflux from cells increasing the intracellular calcium ion concentrations. This cleaves the amyloid precursor protein to produce soluble amyloid beta (sA(). sA( is quickly secreted from cells after production, increasing the levels of sA( in the blood stream. sA( then binds to Apolipoprotein E and apolipoprotein J to be transported to and across the Blood Brain Barrier. Over time, when sufficient sA( have been transported to the brain, a cascade of further events lead to the formation of insoluble neurotoxic beat pleated sheets of amyloid fibril, senile plaques, and eventually AD. The biological mechanism for EMR to cause Alzheimer's disease is well advanced and entirely plausible, commencing with calcium ion efflux. Safe exposure levels by Dr. Neil Cherry
(Altpeter et al. (1995) and Abelin
(1998) - The Schwarzenburg Study) found a causal relationship between sleep
disturbance and subsequent chronic fatigue, and short-wave radio exposures at
extremely low mean levels. The causal relationship between RF radiation exposure and deterioration in
sleep quality is identified through a significant dose response relationship
(p<0.001), Figures 17 and 18, improvements in sleep quality which changing the
direction of the beams and turning the transmitter off, and reduced melatonin as
the biological mechanism.
The causal relationship with human sleep disturbance is strong evidence of a
significant neurological effect of RF radiation on people, associated with mean
exposures down to less than 0.4 nW/cm². Hence, it is highly likely that cell
phone users, with brain exposures many millions of times higher than the
Schwarzenburg exposure levels, will experience significant neurological effects.
The significant bovine behavioural effects of extremely low RF exposure is
confirmed by Löscher and Käs (1998).
Mild et al. (1998) survey around 11,000 cell phone users in Norway and Sweden, Figure 19. They found significant dose response relationships for a number of crucial symptoms that had been clinically described and associated with cell phone use by Hocking (1998). The symptoms include dizziness, a feeling of discomfort, difficulty with concentration, Memory Loss, Fatigue, Headache, Burning Skin and tinglingness and tightness of the skin near the phone. The symptoms were consistent across analogue and digital (GSM) phone users. A dominant physical symptom was a sensation of warmth on the ear and behind the ear. These is not a sensation which is experienced with a conventional telephone but are unique to the cell phone which exposes the user's head to moderate to high intensities of microwaves. It was significant that the neurological symptoms were highly correlated to the warm sensations. The symptoms are consistent with the Schwarzenburg symptoms. The headache symptoms were found with microwave exposure during microwave hearing" experiments, Frey (1998).
Satre, Cook and Graham (1998) observed significantly reduced heart rate
variability (HRV) in volunteers sleeping in 60Hz fields. Extrinsic EMR signals
interfere with hearts and cause heart disease and death. Bortkiewicz et al.
(1995, 1996, 1997) and Szmigielski et al. (1998) found that RF exposure altered
heart rate variability and blood pressure. Braune et al. (1998) showed that cell
phone significantly increased blood pressure. Savitz et al. (1999) found a
highly significant dose response relationship for mortality from Arrhythmia
related heart disease and heart attack (Acute Myocardial Infarction) for exposed
electrical occupations and for individual occupations of electrician, lineman
and power plant operator.
This is a powerful set of epidemiological evidence showing that EMR across
the spectrum increases the incidence and mortality from arrhythmia related heart
disease and from heart attack.
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